Reconstitution of circadian clock in synthetic cells reveals principles of timekeeping

Abstract The cyanobacterial circadian clock maintains remarkable precision and synchrony, even in cells with femtoliter volumes. Here, we reconstitute the KaiABC post-translational oscillator (PTO) in giant unilamellar vesicles (GUVs) to investigate underlying mechanisms of this fidelity. We show th...

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Bibliographic Details
Main Authors: Alexander Zhan Tu Li, Andy LiWang, Anand Bala Subramaniam
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61844-5
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