Pyrazole derivatives as antileishmanial agents: Biological evaluation, molecular docking study, DFT analysis and ADME prediction

Pyrazole derivatives as antileishmanial agents: Biological evaluation, molecular docking study, DFT analysis and ADME prediction

Leishmaniasis is a parasitic disease that is commonly found in tropical and sub-tropical regions. Currently, there is no protective antileishmanial vaccine, and the available clinical drugs have serious side effects. On the other hand, due to the emergence of multidrug-resistant strains of the causa...

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Main Authors: Razieh Sabet, Gholamreza Hatam, Leila Emami, Elaheh Ataollahi, Fateme Zare, Leila Zamani, Behnaz Kazemi, Masood Mohabati Jahromi, Sara Sadeghian, Soghra Khabnadideh
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Heliyon
Subjects:
Pyrazole
Antileishmanial
Molecular docking
DFT analysis
ADME prediction
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024164754
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