A systematic review and network meta-analysis of interventions to preserve insulin-secreting beta cell function in people newly diagnosed with type 1 diabetes: results from randomised controlled trials of immunomodulatory therapies

A systematic review and network meta-analysis of interventions to preserve insulin-secreting beta cell function in people newly diagnosed with type 1 diabetes: results from randomised controlled trials of immunomodulatory therapies

Abstract Background Type 1 diabetes is characterised by the immune-mediated destruction of pancreatic beta cells. We aimed to determine the effectiveness of immunotherapies for preserving residual beta cell function in newly diagnosed (stage 3) type 1 diabetes. Methods Searches were carried out in M...

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Main Authors: Sophie E. Beese, Malcolm J. Price, Claire Tomlinson, Pawana Sharma, Isobel M. Harris, Ada Adriano, Lauren M. Quinn, Ritu Gada, Thomas J. Horgan, Fiona Maggs, Martin Burrows, Krishnarajah Nirantharakumar, G. Neil Thomas, Robert C. Andrews, David J. Moore, Parth Narendran
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Medicine
Subjects:
Systematic review
Network meta-analysis
Type 1 diabetes
Beta cells
Online Access:https://doi.org/10.1186/s12916-025-04201-z
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https://doi.org/10.1186/s12916-025-04201-z

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