Comprehensive N-glycosylation profiling of recombinant spike S1 protein from the wild-type SARS-CoV-2 and its variants

Comprehensive N-glycosylation profiling of recombinant spike S1 protein from the wild-type SARS-CoV-2 and its variants

IntroductionBy 2024, COVID-19 has become endemic, with new variants contributing to its continued spread. The Spike protein forms trimers that bind to the ACE2 receptor on host cells, with the S1 subunit being a primary target for vaccines and antiviral treatments.MethodsHerein, we performed an in-d...

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Main Authors: Yao Peng, Tian-Tian Tong, Qiu-Yu Deng, Lee-Fong Yau, Jia-Qi Qiu, Qing Zhao, Jia-Qi Wu, Zhi-Qiang Xin, Man-Ci Guan, Yue Li, Zhi-Hong Jiang, Hu-Dan Pan, Liang Liu, Jing-Rong Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
spike protein
variants
N-glycans
chip LC/MS
N-glycopeptides
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1592142/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1592142/full

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