Small EVs From Adipose‐Derived MSCs Modulate Epidermal Barrier and Inflammation Via Sphingosine‐1‐Phosphate Signaling Pathway

Small EVs From Adipose‐Derived MSCs Modulate Epidermal Barrier and Inflammation Via Sphingosine‐1‐Phosphate Signaling Pathway

ABSTRACT Epidermal permeability barrier defects are associated with several skin diseases, including atopic dermatitis (AD). Using an AD mouse model, we previously demonstrated that topically administered small extracellular vesicles (sEVs) (prepared following the International Society of Extracellu...

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Main Authors: Kyong‐Oh Shin, Jun Ho Lee, Seungwoo Chae, Karin Goto, Hahyun An, Joan S. Wakefield, Dae Hyun Ha, Healim Lee, Kyojin Lee, Hyunju Lee, Ella Shin, Min Ji Kang, Sinhee Lee, Yoshikazu Uchida, Byong Seung Cho, Kyungho Park
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Journal of Extracellular Vesicles
Subjects:
adipose tissue‐derived mesenchymal stem cells
atopic dermatitis
ceramide metabolic enzyme
lipid
skin
small extracellular vesicles
Online Access:https://doi.org/10.1002/jev2.70121
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https://doi.org/10.1002/jev2.70121

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