Screening key genes for intracranial aneurysm rupture using LASSO regression and the SVM-RFE algorithm

Screening key genes for intracranial aneurysm rupture using LASSO regression and the SVM-RFE algorithm

BackgroundAlthough an intracranial aneurysm (IA) is widespread and fatal, few drugs can be used to prevent its rupture. This study explored the molecular mechanism and potential targets of IA rupture through bioinformatics methods.MethodsThe gene expression matrices of GSE13353, GSE122897, and GSE15...

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Bibliographic Details
Main Authors: Qi Wu, Chunli Yang, Cuilan Huang, Zhiying Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Medicine
Subjects:
LASSO regression
SVM-RFE algorithm
intracranial aneurysm
ROC curve
PPI network
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2024.1487224/full
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