Viral warfare: unleashing engineered oncolytic viruses to outsmart cancer’s defenses

Viral warfare: unleashing engineered oncolytic viruses to outsmart cancer’s defenses

Oncolytic virotherapy (OVT) has emerged as a promising and innovative cancer treatment strategy that harnesses engineered viruses to selectively infect, replicate within, and destroys malignant cells while sparing healthy tissues. Beyond direct oncolysis, oncolytic viruses (OVs) exploit tumor-specif...

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Main Authors: Tolulope O. Omolekan, Joy T. Folahan, Mulu Z. Tesfay, Harikrishnan Mohan, Ojasvi Dutta, Leila Rahimian, Khandoker Usran Ferdous, Reza Ghavimi, Aleksandra Cios, Timothy K. Beng, Joseph Francis, Oswald D'Auvergne, Mitesh J. Borad, Konstantin G. Kousoulas, Stephen DiGiuseppe, Bolni Marius Nagalo, Jean Christopher Chamcheu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
oncolytic viruses
engineered viruses
cancer immunotherapy
combination therapy
immune evasion
pharmacological treatment
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1618751/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1618751/full

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