Influence of SARS-CoV-2 variants of concern and maternal vaccination status on neonatal outcome
SARS-CoV-2 infection during pregnancy can adversely affect maternal and neonatal health, although risks vary depending on the variant of concern (VOC). Omicron, although highly infectious, causes fewer maternal and neonatal complications than earlier VOC, so vaccination may be considered unnecessary...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2025-01-01
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| Series: | BMJ Paediatrics Open |
| Online Access: | https://bmjpaedsopen.bmj.com/content/9/1/e003109.full |
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| author | Rolf Felix Maier Mario Rüdiger Nadine Mand Matthias Hutten Ulrich Pecks |
| author_facet | Rolf Felix Maier Mario Rüdiger Nadine Mand Matthias Hutten Ulrich Pecks |
| author_sort | Rolf Felix Maier |
| collection | DOAJ |
| description | SARS-CoV-2 infection during pregnancy can adversely affect maternal and neonatal health, although risks vary depending on the variant of concern (VOC). Omicron, although highly infectious, causes fewer maternal and neonatal complications than earlier VOC, so vaccination may be considered unnecessary in planned pregnancy. Using data from the CRONOS registry, we compared pregnancy outcomes according to VOC and vaccination status. We found that vaccination during pregnancy reduced preterm birth rates compared with unvaccinated or vaccinated women with Omicron infection, without increasing severe neonatal outcomes. Given the risks associated with preterm birth, the study consistently supports vaccination recommendations for women planning pregnancy. |
| format | Article |
| id | doaj-art-540bd39147334b12bc6246bd7da503d5 |
| institution | Kabale University |
| issn | 2399-9772 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Paediatrics Open |
| spelling | doaj-art-540bd39147334b12bc6246bd7da503d52025-01-07T15:10:09ZengBMJ Publishing GroupBMJ Paediatrics Open2399-97722025-01-019110.1136/bmjpo-2024-003109Influence of SARS-CoV-2 variants of concern and maternal vaccination status on neonatal outcomeRolf Felix Maier0Mario Rüdiger1Nadine Mand2Matthias Hutten3Ulrich Pecks41 Department of Pediatrics, University of Marburg, Marburg, Germany3 Department of Neonatology and Pediatric Intensive Care, Medizinische Fakultät Carl Gustav Carus, TU Dresden, Dresden, Germany1 Department of Pediatrics, University of Marburg, Marburg, Germany2 Department of Pediatrics, Maastricht University, Maastricht, Netherlands4 Department of Obstetrics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, GermanySARS-CoV-2 infection during pregnancy can adversely affect maternal and neonatal health, although risks vary depending on the variant of concern (VOC). Omicron, although highly infectious, causes fewer maternal and neonatal complications than earlier VOC, so vaccination may be considered unnecessary in planned pregnancy. Using data from the CRONOS registry, we compared pregnancy outcomes according to VOC and vaccination status. We found that vaccination during pregnancy reduced preterm birth rates compared with unvaccinated or vaccinated women with Omicron infection, without increasing severe neonatal outcomes. Given the risks associated with preterm birth, the study consistently supports vaccination recommendations for women planning pregnancy.https://bmjpaedsopen.bmj.com/content/9/1/e003109.full |
| spellingShingle | Rolf Felix Maier Mario Rüdiger Nadine Mand Matthias Hutten Ulrich Pecks Influence of SARS-CoV-2 variants of concern and maternal vaccination status on neonatal outcome BMJ Paediatrics Open |
| title | Influence of SARS-CoV-2 variants of concern and maternal vaccination status on neonatal outcome |
| title_full | Influence of SARS-CoV-2 variants of concern and maternal vaccination status on neonatal outcome |
| title_fullStr | Influence of SARS-CoV-2 variants of concern and maternal vaccination status on neonatal outcome |
| title_full_unstemmed | Influence of SARS-CoV-2 variants of concern and maternal vaccination status on neonatal outcome |
| title_short | Influence of SARS-CoV-2 variants of concern and maternal vaccination status on neonatal outcome |
| title_sort | influence of sars cov 2 variants of concern and maternal vaccination status on neonatal outcome |
| url | https://bmjpaedsopen.bmj.com/content/9/1/e003109.full |
| work_keys_str_mv | AT rolffelixmaier influenceofsarscov2variantsofconcernandmaternalvaccinationstatusonneonataloutcome AT mariorudiger influenceofsarscov2variantsofconcernandmaternalvaccinationstatusonneonataloutcome AT nadinemand influenceofsarscov2variantsofconcernandmaternalvaccinationstatusonneonataloutcome AT matthiashutten influenceofsarscov2variantsofconcernandmaternalvaccinationstatusonneonataloutcome AT ulrichpecks influenceofsarscov2variantsofconcernandmaternalvaccinationstatusonneonataloutcome |