Mimicking the Liver Sinusoidal Endothelial Cell Niche In Vitro to Enhance Fenestration in a Genetic Model of Systemic Inflammation

Mimicking the Liver Sinusoidal Endothelial Cell Niche In Vitro to Enhance Fenestration in a Genetic Model of Systemic Inflammation

Liver sinusoidal endothelial cells (LSECs) play a crucial role in hepatic homeostasis, clearance, and microcirculatory regulation. Their fenestrations—patent transcellular pores—are essential for proper liver function, yet disappear in pathological conditions such as liver fibrosis and inflammation...

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Main Authors:	Dibakar Borah, Oliwia Blacharczyk, Karolina Szafranska, Izabela Czyzynska-Cichon, Sara Metwally, Konrad Szymanowski, Wolfgang Hübner, Jerzy Kotlinowski, Ewelina Dobosz, Peter McCourt, Thomas Huser, Malgorzata Lekka, Bartlomiej Zapotoczny
Format:	Article
Language:	English
Published:	MDPI AG 2025-04-01
Series:	Cells
Subjects:	liver sinusoidal endothelial cells polyacrylamide atomic force microscopy elastic properties fenestrations actin cytoskeleton
Online Access:	https://www.mdpi.com/2073-4409/14/8/621
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