Mimicking the Liver Sinusoidal Endothelial Cell Niche In Vitro to Enhance Fenestration in a Genetic Model of Systemic Inflammation

Mimicking the Liver Sinusoidal Endothelial Cell Niche In Vitro to Enhance Fenestration in a Genetic Model of Systemic Inflammation

Liver sinusoidal endothelial cells (LSECs) play a crucial role in hepatic homeostasis, clearance, and microcirculatory regulation. Their fenestrations—patent transcellular pores—are essential for proper liver function, yet disappear in pathological conditions such as liver fibrosis and inflammation...

Full description

Saved in:
Bibliographic Details
Main Authors: Dibakar Borah, Oliwia Blacharczyk, Karolina Szafranska, Izabela Czyzynska-Cichon, Sara Metwally, Konrad Szymanowski, Wolfgang Hübner, Jerzy Kotlinowski, Ewelina Dobosz, Peter McCourt, Thomas Huser, Malgorzata Lekka, Bartlomiej Zapotoczny
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Cells
Subjects:
liver sinusoidal endothelial cells
polyacrylamide
atomic force microscopy
elastic properties
fenestrations
actin cytoskeleton
Online Access:https://www.mdpi.com/2073-4409/14/8/621
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.mdpi.com/2073-4409/14/8/621

Similar Items