Therapeutic correction of ApoER2 splicing in Alzheimer's disease mice using antisense oligonucleotides

Therapeutic correction of ApoER2 splicing in Alzheimer's disease mice using antisense oligonucleotides

Abstract Apolipoprotein E receptor 2 (ApoER2) is an apolipoprotein E receptor involved in long‐term potentiation, learning, and memory. Given its role in cognition and its association with the Alzheimer's disease (AD) risk gene, apoE, ApoER2 has been proposed to be involved in AD, though a role...

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Bibliographic Details
Main Authors: Anthony J Hinrich, Francine M Jodelka, Jennifer L Chang, Daniella Brutman, Angela M Bruno, Clark A Briggs, Bryan D James, Grace E Stutzmann, David A Bennett, Steven A Miller, Frank Rigo, Robert A Marr, Michelle L Hastings
Format: Article
Language:English
Published: Springer Nature 2016-02-01
Series:EMBO Molecular Medicine
Subjects:
Alzheimer's disease
Antisense oligonucleotides
ApoER2
Splicing
Therapeutics
Online Access:https://doi.org/10.15252/emmm.201505846
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https://doi.org/10.15252/emmm.201505846

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