Industrial applicability of enzymatic and whole-cell processes for the utilization of C1 building blocks
Abstract Chemicals produced through enzymatic reactions play a key role in the transition from a linear petrol-dependent to a circular bioeconomy. One promising approach is the conversion of single carbon (C1) molecules by biocatalysts to value-added products. Although progress has been made, curren...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-60777-3 |
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| author | Giovanni Davide Barone Ina Somvilla Hannah Pia Franziska Meier Anna Christina R. Ngo Thomas Bayer Fabio Parmeggiani Viktoria Rehbein Johann A. Hlina Pablo Domínguez de María Uwe T. Bornscheuer Dirk Tischler Sandy Schmidt |
| author_facet | Giovanni Davide Barone Ina Somvilla Hannah Pia Franziska Meier Anna Christina R. Ngo Thomas Bayer Fabio Parmeggiani Viktoria Rehbein Johann A. Hlina Pablo Domínguez de María Uwe T. Bornscheuer Dirk Tischler Sandy Schmidt |
| author_sort | Giovanni Davide Barone |
| collection | DOAJ |
| description | Abstract Chemicals produced through enzymatic reactions play a key role in the transition from a linear petrol-dependent to a circular bioeconomy. One promising approach is the conversion of single carbon (C1) molecules by biocatalysts to value-added products. Although progress has been made, current biological methods remain less cost-competitive than established chemical processes. Here, we review how single and multi-enzyme transformations, natural C1-trophic microorganisms, and organisms with transplanted synthetic C1 assimilation pathways can synergize to strengthen the competitiveness of C1-based biomanufacturing. To explore the current state-of-the-art and assess the potential of C1 biomanufacturing, we highlight the aforementioned bio-based methodologies and evaluate their industrial applicability through an overview of granted patents. |
| format | Article |
| id | doaj-art-53d1e5c0b1e34c1ba80157c0829a69a1 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-53d1e5c0b1e34c1ba80157c0829a69a12025-08-20T03:46:17ZengNature PortfolioNature Communications2041-17232025-08-0116111710.1038/s41467-025-60777-3Industrial applicability of enzymatic and whole-cell processes for the utilization of C1 building blocksGiovanni Davide Barone0Ina Somvilla1Hannah Pia Franziska Meier2Anna Christina R. Ngo3Thomas Bayer4Fabio Parmeggiani5Viktoria Rehbein6Johann A. Hlina7Pablo Domínguez de María8Uwe T. Bornscheuer9Dirk Tischler10Sandy Schmidt11Institute of Molecular Biosciences, University of GrazDepartment of Biotechnology and Enzyme Catalysis, Institute of Biochemistry, University of GreifswaldDepartment of Chemical and Pharmaceutical Biology, University of GroningenMicrobial Biotechnology, Faculty of Biology and Biotechnology, Ruhr University BochumDepartment of Biotechnology and Enzyme Catalysis, Institute of Biochemistry, University of GreifswaldDepartment of Chemistry, Materials and Chemical Engineering “Giulio Natta”, Polytechnic of MilanInstitute of Chemistry, University of GrazInstitute of Chemistry, University of GrazSustainable Momentum SLDepartment of Biotechnology and Enzyme Catalysis, Institute of Biochemistry, University of GreifswaldMicrobial Biotechnology, Faculty of Biology and Biotechnology, Ruhr University BochumDepartment of Chemical and Pharmaceutical Biology, University of GroningenAbstract Chemicals produced through enzymatic reactions play a key role in the transition from a linear petrol-dependent to a circular bioeconomy. One promising approach is the conversion of single carbon (C1) molecules by biocatalysts to value-added products. Although progress has been made, current biological methods remain less cost-competitive than established chemical processes. Here, we review how single and multi-enzyme transformations, natural C1-trophic microorganisms, and organisms with transplanted synthetic C1 assimilation pathways can synergize to strengthen the competitiveness of C1-based biomanufacturing. To explore the current state-of-the-art and assess the potential of C1 biomanufacturing, we highlight the aforementioned bio-based methodologies and evaluate their industrial applicability through an overview of granted patents.https://doi.org/10.1038/s41467-025-60777-3 |
| spellingShingle | Giovanni Davide Barone Ina Somvilla Hannah Pia Franziska Meier Anna Christina R. Ngo Thomas Bayer Fabio Parmeggiani Viktoria Rehbein Johann A. Hlina Pablo Domínguez de María Uwe T. Bornscheuer Dirk Tischler Sandy Schmidt Industrial applicability of enzymatic and whole-cell processes for the utilization of C1 building blocks Nature Communications |
| title | Industrial applicability of enzymatic and whole-cell processes for the utilization of C1 building blocks |
| title_full | Industrial applicability of enzymatic and whole-cell processes for the utilization of C1 building blocks |
| title_fullStr | Industrial applicability of enzymatic and whole-cell processes for the utilization of C1 building blocks |
| title_full_unstemmed | Industrial applicability of enzymatic and whole-cell processes for the utilization of C1 building blocks |
| title_short | Industrial applicability of enzymatic and whole-cell processes for the utilization of C1 building blocks |
| title_sort | industrial applicability of enzymatic and whole cell processes for the utilization of c1 building blocks |
| url | https://doi.org/10.1038/s41467-025-60777-3 |
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