CAV-1 regulates osteocyte communication with osteoclast and osteoblast precursors

CAV-1 regulates osteocyte communication with osteoclast and osteoblast precursors

Abstract Mechanical forces regulate bone homeostasis through complex mechanisms involving diverse mechanoreceptors in osteocytes. PTH/PTHrP receptor type I (PTH1R) regulates the communication with osteoclast precursors by translocating to the primary cilia in osteocytes. Caveolin-1 (CAV-1), the main...

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Main Authors: Joan Pizarro-Gomez, Irene Tirado-Cabrera, Sara Heredero-Jimenez, Eduardo Martin-Guerrero, Sergio Portal-Nuñez, Veronica Alonso, Juan A. Ardura, Arancha Gortazar
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
CAV-1
Osteocyte communication
Osteoclast
PTH1R and PTHrP
Primary cilia
Online Access:https://doi.org/10.1038/s41598-025-08570-6
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https://doi.org/10.1038/s41598-025-08570-6

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