Trial in progress: phase I study of non-viral gene-modified CAR-T cell therapy for malignant solid tumors expressing EPHB4 receptor (CARTiEr)

Trial in progress: phase I study of non-viral gene-modified CAR-T cell therapy for malignant solid tumors expressing EPHB4 receptor (CARTiEr)

BackgroundEphrin type-B receptor 4 (EPHB4) is overexpressed on the surface of various tumor cells, including cells from malignant bone and soft-tissue tumors. AP8901 CAR-T cell therapy can specifically recognize and kill EPHB4 receptor-expressing malignant tumor cells by modifying the natural EPHB4...

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Main Authors: Chikako Funasaka, Yoichi Naito, Hitomi Kubota, Yukiko Ishiguro, Nozomu Fuse, Masashi Wakabayashi, Akihiro Sato, Junichiro Yuda, Genichiro Ishii, Toshihiro Suzuki, Kazumasa Takenouchi, Tetsuya Nakatsura, Konomi Morita, Yoichi Inada, Miyuki Tanaka, Yozo Nakazawa, Shigeki Yagyu, Toshihiko Doi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Oncology
Subjects:
ewing sarcoma
solid tumor
EphB4
CAR-T cell therapy
piggyBac transposon
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1633324/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1633324/full

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