Paradoxical mTORC1-Dependent microRNA-mediated Translation Repression in the Nucleus Accumbens of Male Mice Consuming Alcohol Attenuates Glycolysis

Paradoxical mTORC1-Dependent microRNA-mediated Translation Repression in the Nucleus Accumbens of Male Mice Consuming Alcohol Attenuates Glycolysis

Abstract mTORC1 promotes protein translation, learning and memory, and neuroadaptations that underlie alcohol use disorder (AUD). The mechanisms underlying alcohol-mediated mTORC1-dependent neuroadaptations that drive AUD are not well understood. We report that activation of mTORC1 in the nucleus ac...

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Main Authors: Yann Ehinger, Sophie Laguesse, Khanhky Phamluong, Alexandra Salvi, Yoshitaka J. Sei, Zachary W. Hoisington, Drishti Soneja, Sowmya Gunasekaran, Ken Nakamura, Dorit Ron
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60337-9
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https://doi.org/10.1038/s41467-025-60337-9

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