Enhanced genetic fine mapping accuracy with Bayesian Linear Regression models in diverse genetic architectures.

We evaluated Bayesian Linear Regression (BLR) models with BayesC and BayesR priors as statistical genetic fine-mapping tools, comparing their performance to established methods such as FINEMAP and SuSiE. Through extensive simulations and analyses of UK Biobank (UKB) phenotypes, we assessed F1 classi...

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Bibliographic Details
Main Authors: Merina Shrestha, Zhonghao Bai, Tahereh Gholipourshahraki, Astrid J Hjelholt, Sile Hu, Mads Kjolby, Palle Duun Rohde, Peter Sørensen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-07-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1011783
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