Effect of topical simvastatin (1.2 mg) on gingival crevicular fluid interleukin-6, interleukin-8 and interleukin-10 levels in chronic periodontitis – A clinicobiochemical study
Objectives: The impact of simvastatin (SMV), a cholesterol lowering drug, on bone metabolism appears to involve complex interaction with cholesterol metabolites, hormones, inflammatory mediators and growth factors, thus having direct influence on extent and severity of periodontitis. The present stu...
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Elsevier
2016-05-01
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| Series: | Journal of Oral Biology and Craniofacial Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S221242681500127X |
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| author | Harpreet Singh Grover Shalini Kapoor Ajita Singh |
| author_facet | Harpreet Singh Grover Shalini Kapoor Ajita Singh |
| author_sort | Harpreet Singh Grover |
| collection | DOAJ |
| description | Objectives: The impact of simvastatin (SMV), a cholesterol lowering drug, on bone metabolism appears to involve complex interaction with cholesterol metabolites, hormones, inflammatory mediators and growth factors, thus having direct influence on extent and severity of periodontitis. The present study aims to evaluate the in vivo effect of subgingivally delivered SMV gel (1.2 mg) as a local drug-delivery agent on clinical parameters and on interleukin-6 (IL-6), interleukin-8 (IL-8) and interleukin-10 (IL-10) levels in gingival crevicular fluid (GCF) of chronic periodontitis patients. Materials and methods: 50 patients were selected and categorized into two treatment groups: control (scaling and root planing) and test group (scaling and root planing with SMV gel). At initial appointment, clinical parameters were measured. Biochemical analysis of GCF samples was done to evaluate the amount of IL-6, IL-8 and IL-10. GCF sampling and clinical parameters were repeated at one and three months for both the groups. Results: SMV has an inhibitory effect on pro-inflammatory cytokines (IL-6, IL-8) and stimulatory effect on anti-inflammatory cytokines (IL-10) in GCF of periodontitis patients and has significantly positive effect on all clinical parameters except relative attachment level (RAL). The addition of SMV, thereby, further alters the levels of cytokine that reflect enhanced antibacterial host defence activity at that site. Conclusion: Topical SMV has a beneficial effect on periodontal health. Removal of the bacterial plaque and subgingival delivery of SMV significantly modulates the chemokines present in GCF. To summarize, SMV shows promising role in the management of periodontitis. |
| format | Article |
| id | doaj-art-53494b69373545f3b2ec20a12dfc7e9a |
| institution | Kabale University |
| issn | 2212-4268 |
| language | English |
| publishDate | 2016-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Oral Biology and Craniofacial Research |
| spelling | doaj-art-53494b69373545f3b2ec20a12dfc7e9a2024-11-23T06:26:54ZengElsevierJournal of Oral Biology and Craniofacial Research2212-42682016-05-01628592Effect of topical simvastatin (1.2 mg) on gingival crevicular fluid interleukin-6, interleukin-8 and interleukin-10 levels in chronic periodontitis – A clinicobiochemical studyHarpreet Singh Grover0Shalini Kapoor1Ajita Singh2Professor & H.O.D., Department of Periodontics, SGT Dental College, Haryana, IndiaAssistant Professor, Department of Periodontics, SGT Dental College, Haryana, India; Corresponding author.Postgraduate Student, Department of Periodontics, SGT Dental College, Haryana, IndiaObjectives: The impact of simvastatin (SMV), a cholesterol lowering drug, on bone metabolism appears to involve complex interaction with cholesterol metabolites, hormones, inflammatory mediators and growth factors, thus having direct influence on extent and severity of periodontitis. The present study aims to evaluate the in vivo effect of subgingivally delivered SMV gel (1.2 mg) as a local drug-delivery agent on clinical parameters and on interleukin-6 (IL-6), interleukin-8 (IL-8) and interleukin-10 (IL-10) levels in gingival crevicular fluid (GCF) of chronic periodontitis patients. Materials and methods: 50 patients were selected and categorized into two treatment groups: control (scaling and root planing) and test group (scaling and root planing with SMV gel). At initial appointment, clinical parameters were measured. Biochemical analysis of GCF samples was done to evaluate the amount of IL-6, IL-8 and IL-10. GCF sampling and clinical parameters were repeated at one and three months for both the groups. Results: SMV has an inhibitory effect on pro-inflammatory cytokines (IL-6, IL-8) and stimulatory effect on anti-inflammatory cytokines (IL-10) in GCF of periodontitis patients and has significantly positive effect on all clinical parameters except relative attachment level (RAL). The addition of SMV, thereby, further alters the levels of cytokine that reflect enhanced antibacterial host defence activity at that site. Conclusion: Topical SMV has a beneficial effect on periodontal health. Removal of the bacterial plaque and subgingival delivery of SMV significantly modulates the chemokines present in GCF. To summarize, SMV shows promising role in the management of periodontitis.http://www.sciencedirect.com/science/article/pii/S221242681500127XBone metabolismCytokinesPeriodontal healthGCFHost defence |
| spellingShingle | Harpreet Singh Grover Shalini Kapoor Ajita Singh Effect of topical simvastatin (1.2 mg) on gingival crevicular fluid interleukin-6, interleukin-8 and interleukin-10 levels in chronic periodontitis – A clinicobiochemical study Journal of Oral Biology and Craniofacial Research Bone metabolism Cytokines Periodontal health GCF Host defence |
| title | Effect of topical simvastatin (1.2 mg) on gingival crevicular fluid interleukin-6, interleukin-8 and interleukin-10 levels in chronic periodontitis – A clinicobiochemical study |
| title_full | Effect of topical simvastatin (1.2 mg) on gingival crevicular fluid interleukin-6, interleukin-8 and interleukin-10 levels in chronic periodontitis – A clinicobiochemical study |
| title_fullStr | Effect of topical simvastatin (1.2 mg) on gingival crevicular fluid interleukin-6, interleukin-8 and interleukin-10 levels in chronic periodontitis – A clinicobiochemical study |
| title_full_unstemmed | Effect of topical simvastatin (1.2 mg) on gingival crevicular fluid interleukin-6, interleukin-8 and interleukin-10 levels in chronic periodontitis – A clinicobiochemical study |
| title_short | Effect of topical simvastatin (1.2 mg) on gingival crevicular fluid interleukin-6, interleukin-8 and interleukin-10 levels in chronic periodontitis – A clinicobiochemical study |
| title_sort | effect of topical simvastatin 1 2 mg on gingival crevicular fluid interleukin 6 interleukin 8 and interleukin 10 levels in chronic periodontitis a clinicobiochemical study |
| topic | Bone metabolism Cytokines Periodontal health GCF Host defence |
| url | http://www.sciencedirect.com/science/article/pii/S221242681500127X |
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