Analysis of Risk Factors and the Establishment of a Predictive Model for Thrombosis in Patients with Immune Thrombocytopenia
Objectives To explore the risk factors for thrombi occurring in patients with immune thrombocytopenia (ITP) and establish a risk prediction model to better predict the risk of thrombosis in patients with ITP. Methods We retrospectively analyzed 350 ITP patients who had been hospitalized in the First...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-01-01
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| Series: | Clinical and Applied Thrombosis/Hemostasis |
| Online Access: | https://doi.org/10.1177/10760296241301398 |
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| _version_ | 1841556493109821440 |
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| author | Hui Liang MD Lingxue Duan BSc Manyu Long BSc Songyuan Tie BSc Changyan Sun BSc Sha Ma PhD Jing Wang PhD Shuya Wang BSc |
| author_facet | Hui Liang MD Lingxue Duan BSc Manyu Long BSc Songyuan Tie BSc Changyan Sun BSc Sha Ma PhD Jing Wang PhD Shuya Wang BSc |
| author_sort | Hui Liang MD |
| collection | DOAJ |
| description | Objectives To explore the risk factors for thrombi occurring in patients with immune thrombocytopenia (ITP) and establish a risk prediction model to better predict the risk of thrombosis in patients with ITP. Methods We retrospectively analyzed 350 ITP patients who had been hospitalized in the First People's Hospital of Yunnan Province between January 2024 and June 2024. For all patients, we recorded demographic characteristics and clinical data, analyzed the risk factors for thrombosis in ITP patients and then developed a risk prediction model. Results Stepwise logistic regression analysis indicated that a high D-dimer level, a low PC (platelet count) and a high Padua score were independent risk factors for thrombosis in ITP patients. According to multivariate analysis, a predictive model for thrombus risk showed that the area; the area under the ROC curve (AUC) was 0.673 (95% CI: 0.615-0.730) and the maximum Youden index, sensitivity and specificity were 0.272, 47.0% and 80.2%, respectively. Conclusion A high D-dimer level, low PC, and high Padua score were shown to be independent risk factors for thrombosis in ITP patients. Also, the study showed that these three risk factors might be used as a risk predictors for thrombosis in ITP patients to some extent. |
| format | Article |
| id | doaj-art-5301b8061d664f2eb911e705c2f8c9c8 |
| institution | Kabale University |
| issn | 1938-2723 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical and Applied Thrombosis/Hemostasis |
| spelling | doaj-art-5301b8061d664f2eb911e705c2f8c9c82025-01-07T08:04:13ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232025-01-013110.1177/10760296241301398Analysis of Risk Factors and the Establishment of a Predictive Model for Thrombosis in Patients with Immune ThrombocytopeniaHui Liang MDLingxue Duan BScManyu Long BScSongyuan Tie BScChangyan Sun BScSha Ma PhDJing Wang PhDShuya Wang BScObjectives To explore the risk factors for thrombi occurring in patients with immune thrombocytopenia (ITP) and establish a risk prediction model to better predict the risk of thrombosis in patients with ITP. Methods We retrospectively analyzed 350 ITP patients who had been hospitalized in the First People's Hospital of Yunnan Province between January 2024 and June 2024. For all patients, we recorded demographic characteristics and clinical data, analyzed the risk factors for thrombosis in ITP patients and then developed a risk prediction model. Results Stepwise logistic regression analysis indicated that a high D-dimer level, a low PC (platelet count) and a high Padua score were independent risk factors for thrombosis in ITP patients. According to multivariate analysis, a predictive model for thrombus risk showed that the area; the area under the ROC curve (AUC) was 0.673 (95% CI: 0.615-0.730) and the maximum Youden index, sensitivity and specificity were 0.272, 47.0% and 80.2%, respectively. Conclusion A high D-dimer level, low PC, and high Padua score were shown to be independent risk factors for thrombosis in ITP patients. Also, the study showed that these three risk factors might be used as a risk predictors for thrombosis in ITP patients to some extent.https://doi.org/10.1177/10760296241301398 |
| spellingShingle | Hui Liang MD Lingxue Duan BSc Manyu Long BSc Songyuan Tie BSc Changyan Sun BSc Sha Ma PhD Jing Wang PhD Shuya Wang BSc Analysis of Risk Factors and the Establishment of a Predictive Model for Thrombosis in Patients with Immune Thrombocytopenia Clinical and Applied Thrombosis/Hemostasis |
| title | Analysis of Risk Factors and the Establishment of a Predictive Model for Thrombosis in Patients with Immune Thrombocytopenia |
| title_full | Analysis of Risk Factors and the Establishment of a Predictive Model for Thrombosis in Patients with Immune Thrombocytopenia |
| title_fullStr | Analysis of Risk Factors and the Establishment of a Predictive Model for Thrombosis in Patients with Immune Thrombocytopenia |
| title_full_unstemmed | Analysis of Risk Factors and the Establishment of a Predictive Model for Thrombosis in Patients with Immune Thrombocytopenia |
| title_short | Analysis of Risk Factors and the Establishment of a Predictive Model for Thrombosis in Patients with Immune Thrombocytopenia |
| title_sort | analysis of risk factors and the establishment of a predictive model for thrombosis in patients with immune thrombocytopenia |
| url | https://doi.org/10.1177/10760296241301398 |
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