The proline-rich antimicrobial peptide Api137 disrupts large ribosomal subunit assembly and induces misfolding

The proline-rich antimicrobial peptide Api137 disrupts large ribosomal subunit assembly and induces misfolding

Abstract The proline-rich antimicrobial designer peptide Api137 inhibits protein expression in bacteria by binding simultaneously to the ribosomal polypeptide exit tunnel and the release factor (RF), depleting the cellular RF pool and leading to ribosomal arrest at stop codons. This study investigat...

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Main Authors: Simon Malte Lauer, Jakob Gasse, Andor Krizsan, Maren Reepmeyer, Thiemo Sprink, Rainer Nikolay, Christian M. T. Spahn, Ralf Hoffmann
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-55836-8
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https://doi.org/10.1038/s41467-025-55836-8

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