Autophagy-lysosome pathway in insulin & glucagon homeostasis

Autophagy-lysosome pathway in insulin & glucagon homeostasis

Lysosome, a highly dynamic organelle, is an important nutrient sensing center. They utilize different ion channels and transporters to complete the mission in degradation, trafficking, nutrient sensing and integration of various metabolic pathways to maintain cellular homeostasis. Glucose homeostasi...

Full description

Saved in:

Bibliographic Details
Main Authors:	Yi Wu, Hui Wang, Huoyan Xu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-02-01
Series:	Frontiers in Endocrinology
Subjects:	lysosome autophagy insulin homeostasis glucagon homeostasis diabetes
Online Access:	https://www.frontiersin.org/articles/10.3389/fendo.2025.1541794/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Characterization of LY3324954 a long-acting glucagon-receptor agonist
by: William Roell, et al.
Published: (2025-01-01)

How close is autophagy-targeting therapy for Alzheimer's disease to clinical use? A summary of autophagy modulators in clinical studies
by: Sofia Miranda Fernandes, et al.
Published: (2025-01-01)

Inducers of Autophagy and Cell Death: Focus on Copper Metabolism
by: Weikang Ling, et al.
Published: (2025-01-01)

Different post-pancreatectomy glucagon responses to a meal test between surgical approaches
by: Tsuguka Matsuda, et al.
Published: (2023-11-01)

Resveratrol, a food-derived polyphenol, promotes Melanosomal degradation in skin fibroblasts through coordinated activation of autophagy, lysosomal, and antioxidant pathways
by: Saki Okamoto, et al.
Published: (2025-02-01)

A review on mechanisms of action of bioactive peptides against glucose intolerance and insulin resistance
by: Forough Jahandideh, et al.
Published: (2022-11-01)

Nonlinear association between depressive symptoms and homeostasis model assessment of insulin resistance: a cross-sectional analysis in the American population
by: Chunqi Jiang, et al.
Published: (2025-01-01)

Nutritional state-dependent modulation of insulin-producing cells in Drosophila
by: Rituja S Bisen, et al.
Published: (2025-01-01)

Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis
by: Jiayin Wang, et al.
Published: (2025-01-01)

Copper homeostasis; A rapier between mycobacteria and macrophages
by: Di Hu, et al.
Published: (2025-01-01)

Targeting ion homeostasis in metabolic diseases: Molecular mechanisms and targeted therapies
by: Yanjiao Zhang, et al.
Published: (2025-02-01)

Detection of Insulin in Insulin-Deficient Islets of Patients with Type 1 Diabetes
by: Yuliya Krivova, et al.
Published: (2025-01-01)

Transcriptome analysis reveals effects of ethynylestradiol and bisphenol A on multiple endocrine and metabolic pathways in the pituitary and liver of female Atlantic cod (Gadus morhua)
by: Fekadu Yadetie, et al.
Published: (2025-01-01)

Lysosome-related proteins may have changes in the urinary exosomes of patients with acute gout attack
by: Jitu Wang, et al.
Published: (2025-01-01)

Internal connections between dietary intake and gut microbiota homeostasis in disease progression of ulcerative colitis: a review
by: Wen Zeng, et al.
Published: (2021-03-01)

Peroxiredoxin 6 maintains mitochondrial homeostasis and promotes tumor progression through ROS/JNK/p38 MAPK signaling pathway in multiple myeloma
by: Dandan Gao, et al.
Published: (2025-01-01)

Role of hepatocyte RIPK1 in maintaining liver homeostasis during metabolic challenges
by: Weigao Zhang, et al.
Published: (2025-01-01)

Role of copper homeostasis and cuproptosis in heart failure pathogenesis: implications for therapeutic strategies
by: Zhichao Liu, et al.
Published: (2025-01-01)

Tubular MYDGF Slows Progression of Chronic Kidney Disease by Maintaining Mitochondrial Homeostasis
by: Xiaohan Liu, et al.
Published: (2025-01-01)

Canonical and noncanonical autophagy: involvement in Parkinson’s disease
by: Maria Sakurai, et al.
Published: (2025-01-01)

Communication between endothelial cells and osteoblasts in regulation of bone homeostasis: Notch players
by: Daria Perepletchikova, et al.
Published: (2025-02-01)

Glucagon, rather than Glucagon-Like Peptide 1, Mediates Higher Post-Lunch Glucose Excursions during Breakfast Skipping in Asian Indian Patients with Uncontrolled Type 2 Diabetes Mellitus
by: Yash V. Chauhan, et al.
Published: (2024-12-01)

Theasinensin A attenuated diabetic development by restoring glucose homeostasis, improving hepatic steatosis and modulating gut microbiota in high-fat-diet/streptozotocin-induced diabetic mice
by: Weiqi Xu, et al.
Published: (2023-11-01)

Dendrobium species regulate energy homeostasis in neurodegenerative diseases: a review
by: Feixuan Wang, et al.
Published: (2023-11-01)

The Physiological Role of GABA in Fine-Tuning Control of Blood Glucose and Diabetes Treatment
by: Mohsen Davari, et al.
Published: (2024-12-01)

Cognitive disorders: Potential astrocyte-based mechanism
by: Shiyu Li, et al.
Published: (2025-01-01)

Deferasirox improved iron homeostasis and hematopoiesis in ovariectomized rats with iron accumulation
by: Niloofar Honari, et al.
Published: (2025-01-01)

Improving ferroptosis-mediated immunotherapy for colorectal cancer through lysosome-targeted photodynamic therapy
by: Zhian Chen, et al.
Published: (2025-04-01)

Parameters identification for a model of T cell homeostasis
by: Houssein Ayoub, et al.
Published: (2015-05-01)

Notoginsenoside R1 Attenuates H/R Injury in H9c2 Cells by Maintaining Mitochondrial Homeostasis
by: Yuanbo Xu, et al.
Published: (2025-01-01)

Editorial: Galectins and hormones in health and disease
by: María F. Troncoso, et al.
Published: (2025-02-01)

A wheat germ-rich diet preserves bone homeostasis by regulating gut microbiota and plasma metabolites in aged rats
by: Luanfeng Wang, et al.
Published: (2024-11-01)

GDF11 restores the impaired function of EPCs-MA by promoting autophagy: GDF11 ameliorates endothelial progenitor cell aging by promoting autophagy
by: Liu Donghua, et al.
Published: (2025-01-01)

Research Progress on Metabolic Regulation of Lysosomes and Their Regulatory Mechanism on Meat Tenderness
by: DONG Yushan, DU Rui, SU Rina, YAO Lili, DU Xuerong, LI Chenlong, WU Junqin, HOU Yanru, LUO Yulong
Published: (2025-02-01)

In Situ Transformable Nanoparticle Effectively Suppresses Bladder Cancer by Damaging Mitochondria and Blocking Mitochondrial Autophagy Flux
by: Yulin Lv, et al.
Published: (2025-02-01)

Analysis of the genotype × environment interactions and assessment of the adaptability potential in barley under the conditions of the Northern Trans-Urals
by: N. V. Tetyannikov, et al.
Published: (2021-10-01)

Associations between environmental glyphosate exposure and glucose homeostasis indices in US general adults: a national population-based cross-sectional study
by: Xiaobing Feng, et al.
Published: (2025-01-01)

Effects of Duhuo Jisheng Decoction on Calcium Homeostasis and Apoptosis of Chondrocytes under Endoplasmic Reticulum Stress
by: Qing LIN, et al.
Published: (2020-12-01)

Glucagon: a potential protective factor against peripheral nerve compromise in patients with type 2 diabetes and obesity
by: Hao Hua, et al.
Published: (2025-01-01)

Prmt5 is essential for intestinal stem cell maintenance and homeostasis
by: Li Yang, et al.
Published: (2025-02-01)