Psychedelics for Brain Injury: A Mini-Review
Objective: Stroke and traumatic brain injury (TBI) are among the leading causes of disability. Even after engaging in rehabilitation, nearly half of patients with severe TBI requiring hospitalization are left with major disability. Despite decades of investigation, pharmacologic treatment of brain i...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-07-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2021.685085/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841546504465022976 |
|---|---|
| author | Mia Khan Gregory T. Carter Sunil K. Aggarwal Julie Holland |
| author_facet | Mia Khan Gregory T. Carter Sunil K. Aggarwal Julie Holland |
| author_sort | Mia Khan |
| collection | DOAJ |
| description | Objective: Stroke and traumatic brain injury (TBI) are among the leading causes of disability. Even after engaging in rehabilitation, nearly half of patients with severe TBI requiring hospitalization are left with major disability. Despite decades of investigation, pharmacologic treatment of brain injury is still a field in its infancy. Recent clinical trials have begun into the use of psychedelic therapeutics for treatment of brain injury. This brief review aims to summarize the current state of the science's relevance to neurorehabilitation, and may act as a resource for those seeking to understand the precedence for these ongoing clinical trials.Methods: Narrative mini-review of studies published related to psychedelic therapeutics and brain injury.Results: Recent in vitro, in vivo, and case report studies suggest psychedelic pharmacotherapies may influence the future of brain injury treatment through modulation of neuroinflammation, hippocampal neurogenesis, neuroplasticity, and brain complexity.Conclusions: Historical data on the safety of some of these substances could serve in effect as phase 0 and phase I studies. Further phase II trials will illuminate how these drugs may treat brain injury, particularly TBI and reperfusion injury from stroke. |
| format | Article |
| id | doaj-art-523f2211149d42d6a4134ae1c0410177 |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-523f2211149d42d6a4134ae1c04101772025-01-10T16:28:35ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-07-011210.3389/fneur.2021.685085685085Psychedelics for Brain Injury: A Mini-ReviewMia Khan0Gregory T. Carter1Sunil K. Aggarwal2Julie Holland3Washington University School of Medicine in St. Louis, St. Louis, MO, United StatesDepartment of Physical Medicine & Rehabilitation, St. Luke's Rehabilitation Institute, Spokane, WA, United StatesAdvanced Integrative Medical Sciences Institute, Seattle, WA, United StatesPrivate Practitioner, New York, NY, United StatesObjective: Stroke and traumatic brain injury (TBI) are among the leading causes of disability. Even after engaging in rehabilitation, nearly half of patients with severe TBI requiring hospitalization are left with major disability. Despite decades of investigation, pharmacologic treatment of brain injury is still a field in its infancy. Recent clinical trials have begun into the use of psychedelic therapeutics for treatment of brain injury. This brief review aims to summarize the current state of the science's relevance to neurorehabilitation, and may act as a resource for those seeking to understand the precedence for these ongoing clinical trials.Methods: Narrative mini-review of studies published related to psychedelic therapeutics and brain injury.Results: Recent in vitro, in vivo, and case report studies suggest psychedelic pharmacotherapies may influence the future of brain injury treatment through modulation of neuroinflammation, hippocampal neurogenesis, neuroplasticity, and brain complexity.Conclusions: Historical data on the safety of some of these substances could serve in effect as phase 0 and phase I studies. Further phase II trials will illuminate how these drugs may treat brain injury, particularly TBI and reperfusion injury from stroke.https://www.frontiersin.org/articles/10.3389/fneur.2021.685085/fullpsychedelicsneuroinflammationneuroplasticitystrokebrain injuryreview |
| spellingShingle | Mia Khan Gregory T. Carter Sunil K. Aggarwal Julie Holland Psychedelics for Brain Injury: A Mini-Review Frontiers in Neurology psychedelics neuroinflammation neuroplasticity stroke brain injury review |
| title | Psychedelics for Brain Injury: A Mini-Review |
| title_full | Psychedelics for Brain Injury: A Mini-Review |
| title_fullStr | Psychedelics for Brain Injury: A Mini-Review |
| title_full_unstemmed | Psychedelics for Brain Injury: A Mini-Review |
| title_short | Psychedelics for Brain Injury: A Mini-Review |
| title_sort | psychedelics for brain injury a mini review |
| topic | psychedelics neuroinflammation neuroplasticity stroke brain injury review |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2021.685085/full |
| work_keys_str_mv | AT miakhan psychedelicsforbraininjuryaminireview AT gregorytcarter psychedelicsforbraininjuryaminireview AT sunilkaggarwal psychedelicsforbraininjuryaminireview AT julieholland psychedelicsforbraininjuryaminireview |