Cell Senescence and the DNA Single-Strand Break Damage Repair Pathway

Cell Senescence and the DNA Single-Strand Break Damage Repair Pathway

Cellular senescence is a response to endogenous and exogenous stresses, including telomere dysfunction, oncogene activation, and persistent DNA damage. In particular, radiation damage induces oxidative base damage and bond breaking in the DNA double-helix structure, which are treated by dedicated en...

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Bibliographic Details
Main Authors: Parvathy A. Sarma, Corinne Abbadie, Yvan de Launoit, Fabrizio Cleri
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:DNA
Subjects:
cell senescence
DNA damage
radiotherapy
DNA repair pathways
base-excision repair
single-strand breaks
Online Access:https://www.mdpi.com/2673-8856/4/4/36
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