Hypoxia-induced PRMT1 methylates HIF2β to promote breast tumorigenesis via enhancing glycolytic gene transcription

Hypoxia-induced PRMT1 methylates HIF2β to promote breast tumorigenesis via enhancing glycolytic gene transcription

Summary: Hypoxia-induced metabolic reprogramming is closely linked to breast cancer progression. Through transcriptomic analysis, we identified PRMT1 as a direct target of hypoxia-inducible factor 1α (HIF1α) under hypoxic conditions in breast cancer cells. In turn, PRMT1 enhances the expression of H...

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Main Authors: Wen-juan Li, Yan-chao Chen, Yi-an Lin, Yi-qin Zou, Guo-sheng Hu, Jing-jing Yang, Xin-yu Nie, Mei-yan Li, Yi-ran Wang, Yao-hui He, Yan Zhao, Yu-hua Tan, Xianming Deng, Wei-ling He, Yan Cheng, Fang-meng Fu, Wen Liu
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Cell Reports
Subjects:
CP: Cancer
CP: Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472500258X
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