Expressed mutated genes in Sezary syndrome and their potential prognostic value in patients treated with extracorporeal photopheresis

Expressed mutated genes in Sezary syndrome and their potential prognostic value in patients treated with extracorporeal photopheresis

BackgroundSézary syndrome (SS) is an aggressive and leukemic variant of Cutaneous T-cell Lymphoma (CTCL) with an incidence of 1 case per million people per year. It is characterized by a complex and heterogeneous profile of genetic alteration ns that has so far precluded the development of a specifi...

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Main Authors: Cristina Cristofoletti, Giulia Salvatore, Cristian Bassi, Massimo Negrini, Giovanni Luca Scaglione, Luca Mazzarella, Gianmaria Frigè, Ylenia Aura Minafò, Martina Fioretti, Alessandro Monopoli, Maria Pina Accetturi, Maria Antonietta Pilla, Cosimo Di Raimondo, Alessandra Frezzolini, Enrico Scala, Stefania D’Atri, Giandomenico Russo, Maria Grazia Narducci
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
cutaneous T-cell lymphoma
Sezary syndrome
RNA-seq
whole exome sequencing
extracorporeal photopheresis
candidates associated with therapy resistance and personalized treatment
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1589467/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1589467/full

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