Successful treatment of advanced Birt-Hogg-Dubé syndrome-associated renal cell carcinoma with sarcomatoid dedifferentiation using anlotinib combined with PD-1 inhibitor after first-line therapy failure: a case report

Successful treatment of advanced Birt-Hogg-Dubé syndrome-associated renal cell carcinoma with sarcomatoid dedifferentiation using anlotinib combined with PD-1 inhibitor after first-line therapy failure: a case report

Abstract Background Birt-Hogg-Dubé (BHD) syndrome is a rare autosomal dominant inherited disease caused by germline mutations in the FLCN (folliculin) gene. It often presents as skin fibrofolliculoma, pneumothorax and renal cell carcinoma. BHD syndrome-associated renal cell carcinoma usually present...

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Bibliographic Details
Main Authors: Liqi Yi, Chuang Li, Danfeng Xu, Le Xu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:World Journal of Surgical Oncology
Subjects:
Birt-Hogg-Dubé syndrome
Renal cell carcinoma
Sarcomatoid dedifferentiation
Anlotinib
PD-1 inhibitor
Online Access:https://doi.org/10.1186/s12957-025-03941-9
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https://doi.org/10.1186/s12957-025-03941-9

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