Antibacterial and Inhibitory Activity of Nora and Mepa Efflux Pumps of Estragole Complexed to β-Cyclodextrin (ES/β-CD) In Vitro Against <i>Staphylococcus aureus</i> Bacteria, Molecular Docking and MPO-Based Pharmacokinetics Prediction

Antibacterial and Inhibitory Activity of Nora and Mepa Efflux Pumps of Estragole Complexed to β-Cyclodextrin (ES/β-CD) In Vitro Against <i>Staphylococcus aureus</i> Bacteria, Molecular Docking and MPO-Based Pharmacokinetics Prediction

<b>Background/Objectives:</b> The work investigates the effect of the estragole complex encapsulated in beta-cyclodextrin (ES/β-CD) in modulating bacterial resistance, specifically in <i>Staphylococcus aureus</i> strains expressing NorA and MepA efflux pumps. Efflux pumps are...

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Main Authors: Roger Henrique Sousa da Costa, Renata Torres Pessoa, Eduardo dos Santos Silva, Isaac Moura Araujo, Sheila Alves Gonçalves, Janaína Esmeraldo Rocha, Francisco Nascimento Pereira Junior, Naiara Cipriano Oliveira, Victor Moreira de Oliveira, Matheus Nunes da Rocha, Emmanuel Silva Marinho, Natália Kelly Gomes de Carvalho, José Galberto Martins da Costa, Hélcio Silva dos Santos, Irwin Rose Alencar de Menezes
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Pharmaceutics
Subjects:
efflux pump
terpenes
bacterial resistance
estragole
Online Access:https://www.mdpi.com/1999-4923/16/11/1469
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