Single modality radical radiotherapy is an acceptable alternative for the older patient with squamous cell carcinoma of the oesophagus
Background Oesophageal cancer remains a common cause of cancer mortality worldwide. Increasingly, oncology centres are treating an older population and comorbidities may preclude multimodality treatment with chemoradiotherapy (CRT). We review outcomes of radical radiotherapy (RT) in an older populat...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2021-10-01
|
| Series: | BMJ Open Gastroenterology |
| Online Access: | https://bmjopengastro.bmj.com/content/8/1/e000492.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846138022062456832 |
|---|---|
| author | Philip McLoone Sarah Derby David McIntosh Matthew Forshaw Caroline Lowrie Derek Grose Husam Marashi Christina Wilson |
| author_facet | Philip McLoone Sarah Derby David McIntosh Matthew Forshaw Caroline Lowrie Derek Grose Husam Marashi Christina Wilson |
| author_sort | Philip McLoone |
| collection | DOAJ |
| description | Background Oesophageal cancer remains a common cause of cancer mortality worldwide. Increasingly, oncology centres are treating an older population and comorbidities may preclude multimodality treatment with chemoradiotherapy (CRT). We review outcomes of radical radiotherapy (RT) in an older population treating squamous cell carcinoma (SCC) oesophagus.Methods Patients over 65 years receiving RT for SCC oesophagus between 2013 and 2016 in the West of Scotland were identified. Kaplan-Meier and Cox-regression analysis were used to compare overall survival (OS) between patients treated with radical RT and radical CRT.Results There were 83 patients over 65 years treated with either RT (n=21) or CRT (n=62). There was no significant difference in median OS between CRT versus RT (26.8 months vs 28.5 months, p=0.92). All patients receiving RT completed their treatment whereas 11% of CRT patients did not complete treatment.Conclusion Survival in this non-trial older patient group managed with CRT is comparable to that reported in previous trials. RT shows better than expected outcomes which may reflect developments in RT technique. This review supports RT as an alternative in older patients, unfit for concurrent treatment. |
| format | Article |
| id | doaj-art-51d6749b614a4e64a41c38496f2ba94e |
| institution | Kabale University |
| issn | 2054-4774 |
| language | English |
| publishDate | 2021-10-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Gastroenterology |
| spelling | doaj-art-51d6749b614a4e64a41c38496f2ba94e2024-12-07T15:35:09ZengBMJ Publishing GroupBMJ Open Gastroenterology2054-47742021-10-018110.1136/bmjgast-2020-000492Single modality radical radiotherapy is an acceptable alternative for the older patient with squamous cell carcinoma of the oesophagusPhilip McLoone0Sarah Derby1David McIntosh2Matthew Forshaw3Caroline Lowrie4Derek Grose5Husam Marashi6Christina Wilson72 Public Health, Institute of Health and Wellbeing, University of Glasgow, Glasgow, UKInstitute of Cancer Sciences, University of Glasgow, Glasgow, UK2 Medical Oncology, Beatson West of Scotland Cancer Centre, Glasgow, UKUpper Gastrointestinal Surgery, Glasgow Royal Infirmary, Glasgow, UKClinical Oncology, Beatson West of Scotland Cancer Centre, Glasgow, UKClinical Oncology, Beatson West of Scotland Cancer Centre, Glasgow, UKClinical Oncology, Beatson West of Scotland Cancer Centre, Glasgow, UKClinical Oncology, Beatson West of Scotland Cancer Centre, Glasgow, UKBackground Oesophageal cancer remains a common cause of cancer mortality worldwide. Increasingly, oncology centres are treating an older population and comorbidities may preclude multimodality treatment with chemoradiotherapy (CRT). We review outcomes of radical radiotherapy (RT) in an older population treating squamous cell carcinoma (SCC) oesophagus.Methods Patients over 65 years receiving RT for SCC oesophagus between 2013 and 2016 in the West of Scotland were identified. Kaplan-Meier and Cox-regression analysis were used to compare overall survival (OS) between patients treated with radical RT and radical CRT.Results There were 83 patients over 65 years treated with either RT (n=21) or CRT (n=62). There was no significant difference in median OS between CRT versus RT (26.8 months vs 28.5 months, p=0.92). All patients receiving RT completed their treatment whereas 11% of CRT patients did not complete treatment.Conclusion Survival in this non-trial older patient group managed with CRT is comparable to that reported in previous trials. RT shows better than expected outcomes which may reflect developments in RT technique. This review supports RT as an alternative in older patients, unfit for concurrent treatment.https://bmjopengastro.bmj.com/content/8/1/e000492.full |
| spellingShingle | Philip McLoone Sarah Derby David McIntosh Matthew Forshaw Caroline Lowrie Derek Grose Husam Marashi Christina Wilson Single modality radical radiotherapy is an acceptable alternative for the older patient with squamous cell carcinoma of the oesophagus BMJ Open Gastroenterology |
| title | Single modality radical radiotherapy is an acceptable alternative for the older patient with squamous cell carcinoma of the oesophagus |
| title_full | Single modality radical radiotherapy is an acceptable alternative for the older patient with squamous cell carcinoma of the oesophagus |
| title_fullStr | Single modality radical radiotherapy is an acceptable alternative for the older patient with squamous cell carcinoma of the oesophagus |
| title_full_unstemmed | Single modality radical radiotherapy is an acceptable alternative for the older patient with squamous cell carcinoma of the oesophagus |
| title_short | Single modality radical radiotherapy is an acceptable alternative for the older patient with squamous cell carcinoma of the oesophagus |
| title_sort | single modality radical radiotherapy is an acceptable alternative for the older patient with squamous cell carcinoma of the oesophagus |
| url | https://bmjopengastro.bmj.com/content/8/1/e000492.full |
| work_keys_str_mv | AT philipmcloone singlemodalityradicalradiotherapyisanacceptablealternativefortheolderpatientwithsquamouscellcarcinomaoftheoesophagus AT sarahderby singlemodalityradicalradiotherapyisanacceptablealternativefortheolderpatientwithsquamouscellcarcinomaoftheoesophagus AT davidmcintosh singlemodalityradicalradiotherapyisanacceptablealternativefortheolderpatientwithsquamouscellcarcinomaoftheoesophagus AT matthewforshaw singlemodalityradicalradiotherapyisanacceptablealternativefortheolderpatientwithsquamouscellcarcinomaoftheoesophagus AT carolinelowrie singlemodalityradicalradiotherapyisanacceptablealternativefortheolderpatientwithsquamouscellcarcinomaoftheoesophagus AT derekgrose singlemodalityradicalradiotherapyisanacceptablealternativefortheolderpatientwithsquamouscellcarcinomaoftheoesophagus AT husammarashi singlemodalityradicalradiotherapyisanacceptablealternativefortheolderpatientwithsquamouscellcarcinomaoftheoesophagus AT christinawilson singlemodalityradicalradiotherapyisanacceptablealternativefortheolderpatientwithsquamouscellcarcinomaoftheoesophagus |