Targeting ATF4-DDIT4/TXNIP induced mitochondrial dysfunction and ferroptosis: ISRIB as novel therapy for septic cardiomyopathy

Targeting ATF4-DDIT4/TXNIP induced mitochondrial dysfunction and ferroptosis: ISRIB as novel therapy for septic cardiomyopathy

Abstract Introduction Sepsis-induced cardiomyopathy (SIC) is a reversible lesion in the early clinical stage, but often induces a high mortality rate in the late stage, and its specific mechanism is unknown. Thus, in-depth exploration of the biological progression mechanism of SIC plays a crucial ro...

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Bibliographic Details
Main Authors: Yiting Chen, Xueping Feng, Zeyu Li, Xinrun Wang, Wei Xiong, Jie Liu, Guotao Wang, Wenye Xu, Rui Jin, Lina Zhang, Zhaoxin Qian
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Translational Medicine
Subjects:
Sepsis-induced cardiomyopathy
Ferroptosis
ISRIB
ATF4
DDIT4
Online Access:https://doi.org/10.1186/s12967-025-06939-9
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https://doi.org/10.1186/s12967-025-06939-9

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