Brain-region-specific lipid dysregulation in L-DOPA-induced dyskinesia in a primate model of Parkinson’s disease

Brain-region-specific lipid dysregulation in L-DOPA-induced dyskinesia in a primate model of Parkinson’s disease

Abstract L-DOPA-induced dyskinesia (LID) is a significant and treatment-limiting complication in Parkinson’s disease (PD) therapy, yet its mechanisms remain poorly understood. We used high-resolution mass spectrometry imaging to map brain-region-specific alterations of glycerophospholipids and sphin...

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Main Authors: Ibrahim Kaya, Theodosia Vallianatou, Anna Nilsson, Patrik Bjärterot, Reza Shariatgorji, Per Svenningsson, Erwan Bezard, Per E. Andrén
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-025-01109-6
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