AbaComplex Enhances Mitochondrial Biogenesis and Adipose Tissue Browning: Implications for Obesity and Glucose Regulation
Adipose tissue, particularly white adipose tissue (WAT), plays a central role in energy storage and metabolic regulation. Excess WAT, especially visceral fat, is strongly linked to metabolic disorders such as obesity and type 2 diabetes. The browning of WAT, whereby white fat cells acquire character...
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2024-12-01
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| author | Serena Sagliocchi Elisabetta Schiano Lucia Acampora Fortuna Iannuzzo Annunziata Gaetana Cicatiello Caterina Miro Annarita Nappi Federica Restolfer Mariano Stornaiuolo Stefano Zarrilli Fabrizia Guerra Gian Carlo Tenore Monica Dentice Ettore Novellino |
| author_facet | Serena Sagliocchi Elisabetta Schiano Lucia Acampora Fortuna Iannuzzo Annunziata Gaetana Cicatiello Caterina Miro Annarita Nappi Federica Restolfer Mariano Stornaiuolo Stefano Zarrilli Fabrizia Guerra Gian Carlo Tenore Monica Dentice Ettore Novellino |
| author_sort | Serena Sagliocchi |
| collection | DOAJ |
| description | Adipose tissue, particularly white adipose tissue (WAT), plays a central role in energy storage and metabolic regulation. Excess WAT, especially visceral fat, is strongly linked to metabolic disorders such as obesity and type 2 diabetes. The browning of WAT, whereby white fat cells acquire characteristics of brown adipose tissue (BAT) with enhanced thermogenic capacity, represents a promising strategy to enhance metabolic health. In this study, we investigated the effects of chronic supplementation with an infusion based on lyophilized, thin nectarines rich in abscisic acid (ABA), named AbaComplex, on promoting browning of WAT and activating BAT in mice. Over 30 days, C57BL/6 mice were treated with the ABA-rich infusion, and various metabolic and molecular parameters were assessed. The results showed that the AbaComplex significantly increased the expression of browning markers, such as UCP1 and PGC1-α, in both visceral and subcutaneous WAT. Additionally, mitochondrial biogenesis and function were enhanced, evidenced by elevated mitochondrial DNA content and activity. The treatment also reduced the weight of WAT (both visceral and subcutaneous) and BAT and significantly improved glucose uptake in WAT via upregulation of GLUT4, suggesting enhanced insulin sensitivity. Overall, the pronounced browning effect in WAT underscores the potential of AbaComplex as a natural approach for combating obesity and improving metabolic health. |
| format | Article |
| id | doaj-art-5135abe2928443b38f1b4feb6795ad18 |
| institution | Kabale University |
| issn | 2304-8158 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj-art-5135abe2928443b38f1b4feb6795ad182025-01-10T13:17:38ZengMDPI AGFoods2304-81582024-12-011414810.3390/foods14010048AbaComplex Enhances Mitochondrial Biogenesis and Adipose Tissue Browning: Implications for Obesity and Glucose RegulationSerena Sagliocchi0Elisabetta Schiano1Lucia Acampora2Fortuna Iannuzzo3Annunziata Gaetana Cicatiello4Caterina Miro5Annarita Nappi6Federica Restolfer7Mariano Stornaiuolo8Stefano Zarrilli9Fabrizia Guerra10Gian Carlo Tenore11Monica Dentice12Ettore Novellino13Department of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Napoli, ItalyInventia Biotech-Healthcare Food Research Center s.r.l., Strada Statale Sannitica KM 20.700, 81020 Caserta, ItalyDepartment of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Napoli, ItalyDepartment of Pharmacy, University of Chieti-Pescara G. D’Annunzio, 66100 Chieti, ItalyDepartment of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Napoli, ItalyDepartment of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Napoli, ItalyDepartment of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Napoli, ItalyDepartment of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Napoli, ItalyDepartment of Pharmacy, University of Naples Federico II, Via Domenico Montesano 59, 80131 Napoli, ItalyDepartment of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Napoli, ItalyInventia Biotech-Healthcare Food Research Center s.r.l., Strada Statale Sannitica KM 20.700, 81020 Caserta, ItalyDepartment of Pharmacy, University of Naples Federico II, Via Domenico Montesano 59, 80131 Napoli, ItalyDepartment of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Napoli, ItalyInventia Biotech-Healthcare Food Research Center s.r.l., Strada Statale Sannitica KM 20.700, 81020 Caserta, ItalyAdipose tissue, particularly white adipose tissue (WAT), plays a central role in energy storage and metabolic regulation. Excess WAT, especially visceral fat, is strongly linked to metabolic disorders such as obesity and type 2 diabetes. The browning of WAT, whereby white fat cells acquire characteristics of brown adipose tissue (BAT) with enhanced thermogenic capacity, represents a promising strategy to enhance metabolic health. In this study, we investigated the effects of chronic supplementation with an infusion based on lyophilized, thin nectarines rich in abscisic acid (ABA), named AbaComplex, on promoting browning of WAT and activating BAT in mice. Over 30 days, C57BL/6 mice were treated with the ABA-rich infusion, and various metabolic and molecular parameters were assessed. The results showed that the AbaComplex significantly increased the expression of browning markers, such as UCP1 and PGC1-α, in both visceral and subcutaneous WAT. Additionally, mitochondrial biogenesis and function were enhanced, evidenced by elevated mitochondrial DNA content and activity. The treatment also reduced the weight of WAT (both visceral and subcutaneous) and BAT and significantly improved glucose uptake in WAT via upregulation of GLUT4, suggesting enhanced insulin sensitivity. Overall, the pronounced browning effect in WAT underscores the potential of AbaComplex as a natural approach for combating obesity and improving metabolic health.https://www.mdpi.com/2304-8158/14/1/48abscisic acidnutraceuticalbrowningthermogenesisobesityglycemic control |
| spellingShingle | Serena Sagliocchi Elisabetta Schiano Lucia Acampora Fortuna Iannuzzo Annunziata Gaetana Cicatiello Caterina Miro Annarita Nappi Federica Restolfer Mariano Stornaiuolo Stefano Zarrilli Fabrizia Guerra Gian Carlo Tenore Monica Dentice Ettore Novellino AbaComplex Enhances Mitochondrial Biogenesis and Adipose Tissue Browning: Implications for Obesity and Glucose Regulation Foods abscisic acid nutraceutical browning thermogenesis obesity glycemic control |
| title | AbaComplex Enhances Mitochondrial Biogenesis and Adipose Tissue Browning: Implications for Obesity and Glucose Regulation |
| title_full | AbaComplex Enhances Mitochondrial Biogenesis and Adipose Tissue Browning: Implications for Obesity and Glucose Regulation |
| title_fullStr | AbaComplex Enhances Mitochondrial Biogenesis and Adipose Tissue Browning: Implications for Obesity and Glucose Regulation |
| title_full_unstemmed | AbaComplex Enhances Mitochondrial Biogenesis and Adipose Tissue Browning: Implications for Obesity and Glucose Regulation |
| title_short | AbaComplex Enhances Mitochondrial Biogenesis and Adipose Tissue Browning: Implications for Obesity and Glucose Regulation |
| title_sort | abacomplex enhances mitochondrial biogenesis and adipose tissue browning implications for obesity and glucose regulation |
| topic | abscisic acid nutraceutical browning thermogenesis obesity glycemic control |
| url | https://www.mdpi.com/2304-8158/14/1/48 |
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