Paradoxical Effect of Myosteatosis on the Immune Checkpoint Inhibitor Response in Metastatic Renal Cell Carcinoma

Paradoxical Effect of Myosteatosis on the Immune Checkpoint Inhibitor Response in Metastatic Renal Cell Carcinoma

ABSTRACT Background Treatment for metastatic renal cell carcinoma (mRCC) has shifted from tyrosine kinase inhibitor (TKI) therapy to immune checkpoint inhibitor (ICI)–based therapy, improving outcomes but with variable individual responses. This study investigated the prognostic implications of pret...

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Main Authors: Jiwoong Yu, Hyeonju Ahn, Kyung Yeon Han, Wan Song, Hyun Hwan Sung, Hwang Gyun Jeon, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Se Hoon Park, Woong‐Yang Park, Ji Hyun Lee, Minyong Kang
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
body composition
immune checkpoint inhibitors
low skeletal muscle mass
metastatic renal cell carcinoma
myosteatosis
single‐cell RNA sequencing
Online Access:https://doi.org/10.1002/jcsm.13758
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