Bispecific antibodies provide broad neutralization of emerging beta-coronaviruses by targeting ACE2 and viral spikes

Bispecific antibodies provide broad neutralization of emerging beta-coronaviruses by targeting ACE2 and viral spikes

Human coronaviruses such as SARS-CoV, MERS-CoV, and SARS-CoV-2 have recurrently emerged as significant pathogens, causing severe respiratory illnesses and presenting challenges to monoclonal antibody therapeutics due to their rapid evolution, particularly the diverse variants of SARS-CoV-2. In this...

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Bibliographic Details
Main Authors: Minghui Li, Chaoyue Zhao, Jialu Shi, Xun Wang, Yuanchen Liu, Xiaoyu Zhao, Guonan Cai, Hin Chu, Pengfei Wang
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Emerging Microbes and Infections
Subjects:
SARS-CoV-2
SARS-CoV
MERS-CoV
beta-coronavirus
bispecific antibody
broadly neutralizing antibody
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2024.2404166
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https://www.tandfonline.com/doi/10.1080/22221751.2024.2404166

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