Liver Transplantation for Liver-Originated Malignancy: A Single Center Experience
Objective: We aimed to evaluate liver transplantation (LT) effectiveness for liver-originated malignancies, focusing on hepatocellular carcinoma (HCC), at a single center. Methods: Retrospective data review of LT cases between 2006 and 2023. Inclusion criteria: no extrahepatic involvement and liver...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2024-07-01
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| Series: | Gazi Medical Journal |
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| Online Access: | https://gazimedj.com/articles/liver-transplantation-for-liver-originated-malignancy-a-single-center-experience/doi/gmj.2024.4143 |
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| author | Ramazan Kozan M. Hakan Sözen Aydın Dalgıç |
| author_facet | Ramazan Kozan M. Hakan Sözen Aydın Dalgıç |
| author_sort | Ramazan Kozan |
| collection | DOAJ |
| description | Objective: We aimed to evaluate liver transplantation (LT) effectiveness for liver-originated malignancies, focusing on hepatocellular carcinoma (HCC), at a single center.
Methods: Retrospective data review of LT cases between 2006 and 2023. Inclusion criteria: no extrahepatic involvement and liver-originated malignancy. Demographic characteristics, etiology, alpha-fetoprotein (AFP) levels, Milan Criteria compliance, pre-transplant treatments, complications, recurrence, and mortality were analyzed.
Results: Fourteen liver-originated tumors underwent LT, half of which were from deceased donors. Hepatitis B virus was the common etiology (71%). The median AFP level was 4 ng/mL. Fifty percent received pre-transplant therapy. Patient survival rates at 1, 3, and 5 years: 72%, 72%, 68% respectively. The recurrence-free survival rates for the same years were 93%.
Conclusion: LT, including living donor LT, is effective for liver-originated tumors, especially HCC. Encouraging survival rates align with the Milan and University of California, San Francisco Criteria. Despite limitations, ongoing research is vital for LT’s role in liver cancer management, considering tumor size, positron emission tomography/computed tomography, grade, and AFP levels for candidate selection beyond the current criteria. |
| format | Article |
| id | doaj-art-5092ab04a60d461daa3fa047e7f70f8c |
| institution | Kabale University |
| issn | 2147-2092 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Gazi Medical Journal |
| spelling | doaj-art-5092ab04a60d461daa3fa047e7f70f8c2025-01-17T06:40:28ZengGalenos Publishing HouseGazi Medical Journal2147-20922024-07-0135333233410.12996/gmj.2024.4143Liver Transplantation for Liver-Originated Malignancy: A Single Center ExperienceRamazan Kozan0https://orcid.org/0000-0002-3835-8759M. Hakan Sözen1https://orcid.org/0000-0002-1282-3413Aydın Dalgıç2https://orcid.org/0000-0002-5872-6096Department of General Surgery Gazi University Faculty of Medicine, Ankara, TürkiyeDepartment of General Surgery Gazi University Faculty of Medicine, Ankara, TürkiyeDepartment of General Surgery Gazi University Faculty of Medicine, Ankara, TürkiyeObjective: We aimed to evaluate liver transplantation (LT) effectiveness for liver-originated malignancies, focusing on hepatocellular carcinoma (HCC), at a single center. Methods: Retrospective data review of LT cases between 2006 and 2023. Inclusion criteria: no extrahepatic involvement and liver-originated malignancy. Demographic characteristics, etiology, alpha-fetoprotein (AFP) levels, Milan Criteria compliance, pre-transplant treatments, complications, recurrence, and mortality were analyzed. Results: Fourteen liver-originated tumors underwent LT, half of which were from deceased donors. Hepatitis B virus was the common etiology (71%). The median AFP level was 4 ng/mL. Fifty percent received pre-transplant therapy. Patient survival rates at 1, 3, and 5 years: 72%, 72%, 68% respectively. The recurrence-free survival rates for the same years were 93%. Conclusion: LT, including living donor LT, is effective for liver-originated tumors, especially HCC. Encouraging survival rates align with the Milan and University of California, San Francisco Criteria. Despite limitations, ongoing research is vital for LT’s role in liver cancer management, considering tumor size, positron emission tomography/computed tomography, grade, and AFP levels for candidate selection beyond the current criteria.https://gazimedj.com/articles/liver-transplantation-for-liver-originated-malignancy-a-single-center-experience/doi/gmj.2024.4143hepatocellular carcinomaliverliver transplantationneuroendocrine tumorprimary liver tumortransplant oncology |
| spellingShingle | Ramazan Kozan M. Hakan Sözen Aydın Dalgıç Liver Transplantation for Liver-Originated Malignancy: A Single Center Experience Gazi Medical Journal hepatocellular carcinoma liver liver transplantation neuroendocrine tumor primary liver tumor transplant oncology |
| title | Liver Transplantation for Liver-Originated Malignancy: A Single Center Experience |
| title_full | Liver Transplantation for Liver-Originated Malignancy: A Single Center Experience |
| title_fullStr | Liver Transplantation for Liver-Originated Malignancy: A Single Center Experience |
| title_full_unstemmed | Liver Transplantation for Liver-Originated Malignancy: A Single Center Experience |
| title_short | Liver Transplantation for Liver-Originated Malignancy: A Single Center Experience |
| title_sort | liver transplantation for liver originated malignancy a single center experience |
| topic | hepatocellular carcinoma liver liver transplantation neuroendocrine tumor primary liver tumor transplant oncology |
| url | https://gazimedj.com/articles/liver-transplantation-for-liver-originated-malignancy-a-single-center-experience/doi/gmj.2024.4143 |
| work_keys_str_mv | AT ramazankozan livertransplantationforliveroriginatedmalignancyasinglecenterexperience AT mhakansozen livertransplantationforliveroriginatedmalignancyasinglecenterexperience AT aydındalgıc livertransplantationforliveroriginatedmalignancyasinglecenterexperience |