A Critical Role for the Mitochondrial Pyruvate Carrier in Hepatic Stellate Cell ActivationSummary

A Critical Role for the Mitochondrial Pyruvate Carrier in Hepatic Stellate Cell ActivationSummary

Background & Aims: Hepatic stellate cells (HSCs) are non-parenchymal cells of the liver that produce the extracellular matrix that forms fibrotic lesions in chronic liver disease, including metabolic dysfunction-associated steatohepatitis (MASH). The mitochondrial pyruvate carrier (MPC) cata...

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Main Authors: Mohammad Habibi, Daniel Ferguson, Sophie J. Eichler, Mandy M. Chan, Christina Fu, Terri A. Pietka, Andrea L. Bredemeyer, Andrew LaPoint, Trevor M. Shew, Mai He, Kim H.H. Liss, Andrew J. Lutkewitte, Kevin Cho, Joel D. Schilling, Gary J. Patti, Brian N. Finck
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Collagen
Fibrosis
HIF1alpha
MASLD
TCA Cycle
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X2500058X
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