Genomic analyses in Cavalier King Charles spaniels identify loci associated with clinical signs of Chiari-like malformation and Syringomyelia

Genomic analyses in Cavalier King Charles spaniels identify loci associated with clinical signs of Chiari-like malformation and Syringomyelia

Abstract Background Chiari-like malformations (CM) and syringomyelia (SM) are common in Cavalier King Charles spaniels (CKCS) leading to variable manifestations of pain and scratch. Inheritance studies suggest a polygenic mode of inheritance and association studies have identified loci associated wi...

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Bibliographic Details
Main Authors: Courtney R. Sparks, Jonah N. Cullen, Michael W. Vandewege, Meghan Leber, Katie M. Minor, Steven G. Friedenberg, Natasha J. Olby
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Veterinary Research
Subjects:
Dog
Neuropathic pain
Genome-Wide association study
Neuropathic itch
Complex trait mapping
Online Access:https://doi.org/10.1186/s12917-025-04754-4
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https://doi.org/10.1186/s12917-025-04754-4

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