Substrate Specificity of ABCB Transporters Predicted by Docking Simulations Can Be Confirmed by Experimental Tests

Substrate Specificity of ABCB Transporters Predicted by Docking Simulations Can Be Confirmed by Experimental Tests

ATP-binding cassette (ABC) transporters, particularly those of subfamily B, are involved in cell detoxification, multidrug resistance, drug treatment pharmacodynamics, and also ecological adaptation. In this regard, ABCB transporters may play a decisive role in the co-evolution between plants and he...

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Bibliographic Details
Main Authors: Mario Röpcke, Sha Lu, Cäcilia Plate, Fee Meinzer, Antonia Lisiecki, Susanne Dobler
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Molecules
Subjects:
ATP-binding cassette (ABC) transporter
large milkweed bug
<i>Oncopeltus fassciatus</i>
cardenolides
co-evolutionary relationships
ATPase activity assays
Online Access:https://www.mdpi.com/1420-3049/29/22/5272
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