PARP4 deficiency enhances sensitivity to ATM inhibitor by impairing DNA damage repair in melanoma

PARP4 deficiency enhances sensitivity to ATM inhibitor by impairing DNA damage repair in melanoma

Abstract Besides the important pathogenic mechanisms of melanoma, including BRAF-driven and immunosuppressive microenvironment, genomic instability and abnormal DNA double-strand breaks (DSB) repair are significant driving forces for its occurrence and development. This suggests investigating novel...

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Bibliographic Details
Main Authors: Yuehua Li, Yu Liu, Jingjing Ma, Yuqi Yang, Qiao Yue, Guannan Zhu, Weinan Guo, Tianwen Gao, Qiong Shi, Chunying Li
Format: Article
Language:English
Published: Nature Publishing Group 2025-01-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02296-0
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