Danlian-Tongmai formula improves diabetic vascular calcification by regulating CCN3/NOTCH signal axis to inhibit inflammatory reaction

Danlian-Tongmai formula improves diabetic vascular calcification by regulating CCN3/NOTCH signal axis to inhibit inflammatory reaction

BackgroundVascular calcification (VC) commonly occurs in diabetes and is associated with cardiovascular disease incidence and mortality. Currently, there is no drug treatment for VC. The Danlian-Tongmai formula (DLTM) is a traditional Chinese medicine (TCM) prescription used for diabetic VC (DVC), b...

Full description

Saved in:

Bibliographic Details
Main Authors:	Wenting Wang, Yiwen Li, Mengmeng Zhu, Qian Xu, Jing Cui, Yanfei Liu, Yue Liu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Series:	Frontiers in Pharmacology
Subjects:	vascular calcification Danlian-Tongmai formula UHPLC-MS CCN3 notch signaling
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1510030/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

CCN1 promotes APRIL/BAFF signaling in esophageal squamous cell carcinoma but attenuates it in esophageal adenocarcinoma
by: Lingling Xing, et al.
Published: (2025-01-01)

CCN3: lactational bone booster
by: Nathan Xu, et al.
Published: (2024-12-01)

Integrated analyses of Mendelian randomization, eQTL, and single-cell transcriptome identify CCN3 as a potential biomarker in aortic dissection
by: Haoyu Ran, et al.
Published: (2024-12-01)

Generalized arterial calcification of infancy – Fetal diagnosis to postnatal management
by: Lamk Kadiyani, et al.
Published: (2024-12-01)

Characteristics and prognostic values of abdominal aortic branches calcification in hemodialysis patients
by: Wen Shi, et al.
Published: (2025-12-01)

Higher serum Metrnl levels are associated with increased vascular calcification in hemodialysis patients
by: Conghui Liu, et al.
Published: (2025-12-01)

Construction of a miR-15a-based risk prediction model for vascular calcification detection in patients undergoing hemodialysis
by: Chen Fu, et al.
Published: (2024-12-01)

Crack initiation at V-notch tip subjected to in-plane mixed mode loading: An application of the fictitious notch rounding concept
by: F. Berto
Published: (2015-09-01)

Calcific tendinitis of the supraspinatus tendon treated with iontophoresis: a case report
by: Sarvenaz Karimi-GhasemAbad, et al.
Published: (2024-12-01)

Ovarian Fibroma with Substantial Calcification: An Uncommon Case Presentation
by: Chendong He, et al.
Published: (2024-11-01)

A case of sclerosing angiomatoid nodular transformation with central calcification
by: Eri Nakamura, MD, et al.
Published: (2025-03-01)

Critical applied stresses for a crack initiation from a sharp V-notch
by: L. Náhlík, et al.
Published: (2014-09-01)

Highly selective-notch band ultrawide band antenna: A review
by: Anees Abbas, et al.
Published: (2025-01-01)

Diagnosis and clinical significance of prostate calcification using computed tomography
by: Seong Cheol Kim, et al.
Published: (2025-02-01)

Association of neutrophil-to-lymphocyte ratio with severe abdominal aortic calcification: new evidence from the United States
by: Hao Deng, et al.
Published: (2025-02-01)

The Frequency of Mediastinal Lymph Node Calcification in Sarcoidosis Patients and the Influencing Factors
by: Pelin Pınar Deniz, et al.
Published: (2024-12-01)

FRACTURE CRITERION OF THE THEORY OF CRITICAL DISTANCE FOR NOTCHES
by: LIU XiaoMei, et al.
Published: (2018-01-01)

Notch sensitivity study in u-notched polymers built by Additive Manufacturing (AM)
by: Jorge Guillermo D�az Rodr�guez, et al.
Published: (2023-10-01)

Role of magnetic resonance imaging in assessment of relationship between intercondylar notch parameters and anterior cruciate ligament injuries
by: Nadine Hamdy Abdel Reheem, et al.
Published: (2025-01-01)

Vitamin K-Dependent Proteins as Predictors of Valvular Calcifications and Mortality in Hemodialysis Patients
by: Marcel Palamar, et al.
Published: (2024-12-01)

Sinomenine attenuates uremia vascular calcification by miR-143-5p
by: Fengyi Yu, et al.
Published: (2025-01-01)

Breast Arterial Calcification on a Screening Mammogram: A Potential Cardiovascular Risk Stratification Tool in Women
by: Ahmed Fathala, et al.
Published: (2024-12-01)

Monitoring of microvascular calcification by time-resolved photoacoustic microscopy
by: Haigang Ma, et al.
Published: (2025-02-01)

Analysis of the relationship between abdominal aortic calcification and frailty in the middle-aged and older US population
by: Rena Rehemuding, et al.
Published: (2025-03-01)

Design of a novel sextuple band-notched UWB antenna
by: Han LIU, et al.
Published: (2016-12-01)

Mechanism of Bushen Huoxue Recipe on Improving Arterial Calcification in Rats with Osteoporosis Based on OPG/RANKL Signaling Pathway
by: LIN Xiaorong, et al.
Published: (2022-08-01)

A new process for extracting vanadium by direct calcification using the heat of molten vanadium slag
by: Qu J.-W., et al.
Published: (2022-01-01)

Endothelial injury is one of the risk factors for the progression of vascular calcification in patients receiving maintenance dialysis
by: Dan-Dan Yao, et al.
Published: (2025-12-01)

Research on naming and addressing technology of the Internet of things
by: Lingyun JIANG, et al.
Published: (2018-09-01)

Study of V-notch fatigue strength based on affected depth approach
by: Youssef, Marwa, et al.
Published: (2024-09-01)

The role of lin-12 notch in C. elegans anchor cell proliferation
by: Alex Hajnal, et al.
Published: (2024-12-01)

Nitrogen-containing bisphosphonate for vascular calcification: animal experiments, systematic review and meta-analysis
by: Wei Xu, et al.
Published: (2025-01-01)

Bacteroides Fragilis Exacerbates T2D Vascular Calcification by Secreting Extracellular Vesicles to Induce M2 Macrophages
by: Cong Chen, et al.
Published: (2025-02-01)

PRECISION COMPARISON METHOD OF EXPANSION DESIGN FORMULA APPLIED RANGE
by: LIU Cen, et al.
Published: (2018-01-01)

Polyfactoriality as a Defining Criterion of Formulaic Speech
by: Günter Schmale
Published: (2020-12-01)

Effect of notch shape on the fracture toughness behavior
by: Jiseung Lee, et al.
Published: (2025-01-01)

Associations between oxidation balance score and abdominal aortic calcification, and the mediating role of glycohemoglobin: a nationally representative cross-sectional study from NHANES
by: Heqian Liu, et al.
Published: (2025-01-01)

A rare case of extrapelvic endometriosis in the right sciatic notch
by: Gregory Liller, DO, et al.
Published: (2025-03-01)

Hepatic Steatosis Aggravates Vascular Calcification via Extracellular Vesicle‐Mediated Osteochondrogenic Switch of Vascular Smooth Muscle Cells
by: Zhao‐Lin Zeng, et al.
Published: (2025-02-01)

Localized COUP‐TFII pDNA Delivery Modulates Stem/Progenitor Cell Differentiation to Enhance Endothelialization and Inhibit Calcification of Decellularized Allografts
by: Mengmeng Xing, et al.
Published: (2025-02-01)