Scalability of spheroid-derived small extracellular vesicles production in stirred systems

Scalability of spheroid-derived small extracellular vesicles production in stirred systems

IntroductionSmall extracellular vesicle (sEV)-based therapies have gained widespread interest, but challenges persist to ensure standardization and high-scale production. Implementing upstream processes in a chemically defined media in stirred-tank bioreactors (STBr) is mandatory to closely control...

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Main Authors: Thibaud Dauphin, Laurence de Beaurepaire, Apolline Salama, Quentin Pruvost, Clémentine Claire, Karine Haurogné, Sophie Sourice, Aurélien Dupont, Jean-Marie Bach, Julie Hervé, Eric Olmos, Steffi Bosch, Blandine Lieubeau, Mathilde Mosser
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
spheroid
extracellular vesicles
bioreactor
bioproduction
bioprocess
scale-up
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2025.1516482/full
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https://www.frontiersin.org/articles/10.3389/fbioe.2025.1516482/full

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