Osteopontin activity modulates sex‐specific calcification in engineered valve tissue mimics

Osteopontin activity modulates sex‐specific calcification in engineered valve tissue mimics

Abstract Patients with aortic valve stenosis (AVS) have sexually dimorphic phenotypes in their valve tissue, where male valvular tissue adopts a calcified phenotype and female tissue becomes more fibrotic. The molecular mechanisms that regulate sex‐specific calcification in valvular tissue remain po...

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Main Authors: Megan E. Schroeder, Dilara Batan, Andrea Gonzalez Rodriguez, Kelly F. Speckl, Douglas K. Peters, Bruce E. Kirkpatrick, Grace K. Hach, Cierra J. Walker, Joseph C. Grim, Brian A. Aguado, Robert M. Weiss, Kristi S. Anseth
Format: Article
Language:English
Published: Wiley 2023-01-01
Series:Bioengineering & Translational Medicine
Subjects:
calcification
osteopontin
sex differences
synthetic hydrogels
valvular interstitial cells
Online Access:https://doi.org/10.1002/btm2.10358
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https://doi.org/10.1002/btm2.10358

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