Inhibiting H3K27 Demethylases Downregulates CREB‐CREBBP, Overcoming Resistance in Relapsed Acute Lymphoblastic Leukemia

Inhibiting H3K27 Demethylases Downregulates CREB‐CREBBP, Overcoming Resistance in Relapsed Acute Lymphoblastic Leukemia

ABSTRACT Background CREB binding protein (CREBBP) is a key epigenetic regulator, altered in a fifth of relapsed cases of acute lymphoblastic leukemia (ALL). Selectively targeting epigenetic signaling may be an effective novel therapeutic approach to overcome drug resistance. Anti‐tumor effects have...

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Bibliographic Details
Main Authors: Juan Lazaro‐Navarro, Clara Alcon, Mathurin Dorel, Lina Alasfar, Lorenz Bastian, Claudia Baldus, Kathy Astrahantseff, Marie‐Laure Yaspo, Joan Montero, Cornelia Eckert
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Cancer Medicine
Subjects:
apoptosis
drug discovery and delivery
epigenetics
leukemia
Online Access:https://doi.org/10.1002/cam4.70596
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https://doi.org/10.1002/cam4.70596

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