Targeting S100A9 attenuates social dysfunction by modulating neuroinflammation and myelination in a mouse model of autism

Targeting S100A9 attenuates social dysfunction by modulating neuroinflammation and myelination in a mouse model of autism

Growing evidence supports a role for dysregulated neuroinflammation in autism. However, the underlying mechanisms of microglia-evoked neuroinflammation in the development of autistic phenotypes have not been elucidated. This study aimed to investigate the role and underlying mechanisms of microglial...

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Bibliographic Details
Main Authors: Hong Gong, Yao Lu, Shi-Long Deng, Ke-Yi Lv, Jing Luo, Yi Luo, Zhu-Lin Du, Ling-Feng Wu, Tian-Yao Liu, Xia-Qing Wang, Jing-Hui Zhao, Lian Wang, Mei-Ling Xia, Dong-Mei Zhu, Li-Wei Wang, Xiao-Tang Fan
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Pharmacological Research
Subjects:
ASD
Mrp14
Neuroinflammation
Microglia
Myelination deficit
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661824005139
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