Endoplasmic reticulum stress related super-enhancers suppress cuproptosis via glycolysis reprogramming in lung adenocarcinoma

Abstract The role of copper in tumor progression is thought to be a double-edged sword. Moderate levels of copper promote tumor progression, while excess copper induces a novel form of programmed cell death known as cuproptosis. However, the relationship between lung adenocarcinoma (LUAD) and cuprop...

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Bibliographic Details
Main Authors: Yan Gu, Hongchang Wang, Wentao Xue, Linjia Zhu, Chenghao Fu, Wenhao Zhang, Guang Mu, Yang Xia, Ke Wei, Jun Wang
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07613-0
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