The novel role of Kallistatin in linking metabolic syndromes and cognitive memory deterioration by inducing amyloid-β plaques accumulation and tau protein hyperphosphorylation

The novel role of Kallistatin in linking metabolic syndromes and cognitive memory deterioration by inducing amyloid-β plaques accumulation and tau protein hyperphosphorylation

Accumulation of amyloid-β (Aβ) peptides and hyperphosphorylated tau proteins in the hippocampus triggers cognitive memory decline in Alzheimer’s disease (AD). The incidence and mortality of sporadic AD were tightly associated with diabetes and hyperlipidemia, while the exact linked molecular mechani...

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Bibliographic Details
Main Authors: Weiwei Qi, Yanlan Long, Ziming Li, Zhen Zhao, Jinhui Shi, Wanting Xie, Laijian Wang, Yandan Tan, Ti Zhou, Minting Liang, Ping Jiang, Bin Jiang, Xia Yang, Guoquan Gao
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-08-01
Series:eLife
Subjects:
Alzheimer's disease
Kallistatin
Aβ42
BACE1
diabetes
Online Access:https://elifesciences.org/articles/99462
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