Assessment of thiamine status and its association with clinical parameters in patients undergoing maintenance hemodialysis
ObjectiveThiamine deficiency is a common complication in end-stage renal disease (ESRD) patients receiving maintenance hemodialysis (HD). The purpose of this cross-sectional study was to assess the prevalence of thiamine deficiency in HD patients and its association with clinical parameters.MethodsT...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1563768/full |
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| author | Bo Yang Naiying Lan Fanzhou Zeng Qing Shao Dan Ye Hao Wang Cheng Xue Nanmei Liu |
| author_facet | Bo Yang Naiying Lan Fanzhou Zeng Qing Shao Dan Ye Hao Wang Cheng Xue Nanmei Liu |
| author_sort | Bo Yang |
| collection | DOAJ |
| description | ObjectiveThiamine deficiency is a common complication in end-stage renal disease (ESRD) patients receiving maintenance hemodialysis (HD). The purpose of this cross-sectional study was to assess the prevalence of thiamine deficiency in HD patients and its association with clinical parameters.MethodsThis was a single-center cross-sectional study that included 113 maintenance HD patients from our hospital. Thiamine status was evaluated by high-performance liquid chromatography on whole blood samples. We evaluated the association between blood thiamine concentration and other clinical parameters, including markers of iron metabolism and cardiac function.ResultsThe prevalence of thiamine deficiency was 11.5%. Univariate analysis revealed a significant positive correlation between thiamine levels and iron metabolism markers, including hemoglobin level (Rho = 0.257, p = 0.006), transferrin saturation (Rho = 0.244, p = 0.009), and serum iron (Rho = 0.213, p = 0.025). A multivariate regression analysis confirmed that thiamine levels were independently associated with hemoglobin levels (beta coefficients = 0.25, p = 0.012).ConclusionThese findings suggest an association between lower thiamine levels and anemia in HD patients. Further research is needed to elucidate the underlying mechanisms and evaluate the efficacy of thiamine supplementation in improving anemia and other clinical outcomes in this population. |
| format | Article |
| id | doaj-art-4e1beff5325342e68b42b51daaf0d142 |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-4e1beff5325342e68b42b51daaf0d1422025-08-20T03:49:32ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-05-011210.3389/fnut.2025.15637681563768Assessment of thiamine status and its association with clinical parameters in patients undergoing maintenance hemodialysisBo Yang0Naiying Lan1Fanzhou Zeng2Qing Shao3Dan Ye4Hao Wang5Cheng Xue6Nanmei Liu7Department of Nephrology, Naval Medical Center of PLA, Naval Medical University, Shanghai, ChinaDepartment of Nephrology, Naval Medical Center of PLA, Naval Medical University, Shanghai, ChinaDepartment of Nephrology, Naval Medical Center of PLA, Naval Medical University, Shanghai, ChinaDepartment of Nephrology, Naval Medical Center of PLA, Naval Medical University, Shanghai, ChinaDepartment of Nephrology, Naval Medical Center of PLA, Naval Medical University, Shanghai, ChinaDepartment of Nephrology, Naval Medical Center of PLA, Naval Medical University, Shanghai, ChinaDivision of Nephrology, Changzheng Hospital, Naval Medical University, Shanghai, ChinaDepartment of Nephrology, Naval Medical Center of PLA, Naval Medical University, Shanghai, ChinaObjectiveThiamine deficiency is a common complication in end-stage renal disease (ESRD) patients receiving maintenance hemodialysis (HD). The purpose of this cross-sectional study was to assess the prevalence of thiamine deficiency in HD patients and its association with clinical parameters.MethodsThis was a single-center cross-sectional study that included 113 maintenance HD patients from our hospital. Thiamine status was evaluated by high-performance liquid chromatography on whole blood samples. We evaluated the association between blood thiamine concentration and other clinical parameters, including markers of iron metabolism and cardiac function.ResultsThe prevalence of thiamine deficiency was 11.5%. Univariate analysis revealed a significant positive correlation between thiamine levels and iron metabolism markers, including hemoglobin level (Rho = 0.257, p = 0.006), transferrin saturation (Rho = 0.244, p = 0.009), and serum iron (Rho = 0.213, p = 0.025). A multivariate regression analysis confirmed that thiamine levels were independently associated with hemoglobin levels (beta coefficients = 0.25, p = 0.012).ConclusionThese findings suggest an association between lower thiamine levels and anemia in HD patients. Further research is needed to elucidate the underlying mechanisms and evaluate the efficacy of thiamine supplementation in improving anemia and other clinical outcomes in this population.https://www.frontiersin.org/articles/10.3389/fnut.2025.1563768/fullthiaminehemodialysisanemiairon metabolismcross-sectional study |
| spellingShingle | Bo Yang Naiying Lan Fanzhou Zeng Qing Shao Dan Ye Hao Wang Cheng Xue Nanmei Liu Assessment of thiamine status and its association with clinical parameters in patients undergoing maintenance hemodialysis Frontiers in Nutrition thiamine hemodialysis anemia iron metabolism cross-sectional study |
| title | Assessment of thiamine status and its association with clinical parameters in patients undergoing maintenance hemodialysis |
| title_full | Assessment of thiamine status and its association with clinical parameters in patients undergoing maintenance hemodialysis |
| title_fullStr | Assessment of thiamine status and its association with clinical parameters in patients undergoing maintenance hemodialysis |
| title_full_unstemmed | Assessment of thiamine status and its association with clinical parameters in patients undergoing maintenance hemodialysis |
| title_short | Assessment of thiamine status and its association with clinical parameters in patients undergoing maintenance hemodialysis |
| title_sort | assessment of thiamine status and its association with clinical parameters in patients undergoing maintenance hemodialysis |
| topic | thiamine hemodialysis anemia iron metabolism cross-sectional study |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1563768/full |
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