Warehouse-based, immunopeptidome-guided design of personalised peptide vaccines shows feasibility in clinical trial evaluation in CLL patients

Warehouse-based, immunopeptidome-guided design of personalised peptide vaccines shows feasibility in clinical trial evaluation in CLL patients

Cancer peptide vaccination represents a promising therapeutic approach, but has been hampered by lack of suitable antigens and restricted applicability due to different HLA backgrounds of individual patients. We here introduce a novel warehouse-based concept for composition of personalized peptide v...

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Main Authors: Jonas S. Heitmann, Susanne Jung, Marcel Wacker, Yacine Maringer, Annika Nelde, Jens Bauer, Monika Denk, Naomi Hoenisch-Gravel, Marion Richter, Melek T. Oezbek, Marissa L. Dubbelaar, Tatjana Bilich, Marina Pumptow, Peter Martus, Gerald Illerhaus, Claudio Denzlinger, Francesca Steinbach, Walter-Erich Aulitzky, Martin R. Müller, Daniela Dörfel, Hans–Georg Rammensee, Helmut R. Salih, Juliane S. Walz
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
Subjects:
CLL
vaccine
peptide
warehouse
immunopeptidome
trial
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1482715/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1482715/full

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