Capsaicin alleviates the hepatic clock gene disruption and gut microbiota dysbiosis in circadian rhythm disorder mouse model
As the body’s internal clock, the circadian rhythm regulates the energy expenditure, appetite, and sleep. There exists a close relationship between the host circadian rhythm and gut microbiota. In this work, a circadian disorder mouse model induced by constant darkness (CD) was constructed to invest...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tsinghua University Press
2024-09-01
|
| Series: | Food Science and Human Wellness |
| Subjects: | |
| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2022.9250238 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841550181579882496 |
|---|---|
| author | Bolin Lin Chi-Tang Ho Yawen Wang Jie Xiao Muwen Lu |
| author_facet | Bolin Lin Chi-Tang Ho Yawen Wang Jie Xiao Muwen Lu |
| author_sort | Bolin Lin |
| collection | DOAJ |
| description | As the body’s internal clock, the circadian rhythm regulates the energy expenditure, appetite, and sleep. There exists a close relationship between the host circadian rhythm and gut microbiota. In this work, a circadian disorder mouse model induced by constant darkness (CD) was constructed to investigate the regulating effects of capsaicin (CAP) on disturbances of metabolism homeostasis and gut microbiota in the respect of circadian rhythm-related mechanisms. Our results indicated that CAP reduced weight gain induced by circadian rhythm disorder in mice by inhibiting fat accumulation in liver and adipose tissue. The rhythmic expressions of circadian clock genes and lipid-metabolism related genes in liver were also recovered by CAP. Microbial study using 16S rRNA sequencing revealed that CAP modulated the gut microbiota richness, diversity and composition, and restored diurnal oscillations of gut microbes at the phylum and family level. These results indicated that CAP could alleviate CD-induced hepatic clock gene disruption and gut microbiota dysbiosis in mice, providing theoretical basis for CAP to be used as a muti-functional ingredient with great health-promoting effects. |
| format | Article |
| id | doaj-art-4e13ab34a60a420fa849b9a90c7b8444 |
| institution | Kabale University |
| issn | 2097-0765 2213-4530 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-4e13ab34a60a420fa849b9a90c7b84442025-01-10T06:56:56ZengTsinghua University PressFood Science and Human Wellness2097-07652213-45302024-09-011352947295810.26599/FSHW.2022.9250238Capsaicin alleviates the hepatic clock gene disruption and gut microbiota dysbiosis in circadian rhythm disorder mouse modelBolin Lin0Chi-Tang Ho1Yawen Wang2Jie Xiao3Muwen Lu4Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science, South China Agricultural University, Guangzhou 510642, ChinaDepartment of Food Science, Rutgers University, New Brunswick 08901, USADepartment of Hematology, The Hospital Affi liated to Qingdao University, Qingdao 266000, ChinaGuangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science, South China Agricultural University, Guangzhou 510642, ChinaGuangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science, South China Agricultural University, Guangzhou 510642, ChinaAs the body’s internal clock, the circadian rhythm regulates the energy expenditure, appetite, and sleep. There exists a close relationship between the host circadian rhythm and gut microbiota. In this work, a circadian disorder mouse model induced by constant darkness (CD) was constructed to investigate the regulating effects of capsaicin (CAP) on disturbances of metabolism homeostasis and gut microbiota in the respect of circadian rhythm-related mechanisms. Our results indicated that CAP reduced weight gain induced by circadian rhythm disorder in mice by inhibiting fat accumulation in liver and adipose tissue. The rhythmic expressions of circadian clock genes and lipid-metabolism related genes in liver were also recovered by CAP. Microbial study using 16S rRNA sequencing revealed that CAP modulated the gut microbiota richness, diversity and composition, and restored diurnal oscillations of gut microbes at the phylum and family level. These results indicated that CAP could alleviate CD-induced hepatic clock gene disruption and gut microbiota dysbiosis in mice, providing theoretical basis for CAP to be used as a muti-functional ingredient with great health-promoting effects.https://www.sciopen.com/article/10.26599/FSHW.2022.9250238capsaicincircadian rhythmhepatic clock genegut microbiotalipid dysregulation |
| spellingShingle | Bolin Lin Chi-Tang Ho Yawen Wang Jie Xiao Muwen Lu Capsaicin alleviates the hepatic clock gene disruption and gut microbiota dysbiosis in circadian rhythm disorder mouse model Food Science and Human Wellness capsaicin circadian rhythm hepatic clock gene gut microbiota lipid dysregulation |
| title | Capsaicin alleviates the hepatic clock gene disruption and gut microbiota dysbiosis in circadian rhythm disorder mouse model |
| title_full | Capsaicin alleviates the hepatic clock gene disruption and gut microbiota dysbiosis in circadian rhythm disorder mouse model |
| title_fullStr | Capsaicin alleviates the hepatic clock gene disruption and gut microbiota dysbiosis in circadian rhythm disorder mouse model |
| title_full_unstemmed | Capsaicin alleviates the hepatic clock gene disruption and gut microbiota dysbiosis in circadian rhythm disorder mouse model |
| title_short | Capsaicin alleviates the hepatic clock gene disruption and gut microbiota dysbiosis in circadian rhythm disorder mouse model |
| title_sort | capsaicin alleviates the hepatic clock gene disruption and gut microbiota dysbiosis in circadian rhythm disorder mouse model |
| topic | capsaicin circadian rhythm hepatic clock gene gut microbiota lipid dysregulation |
| url | https://www.sciopen.com/article/10.26599/FSHW.2022.9250238 |
| work_keys_str_mv | AT bolinlin capsaicinalleviatesthehepaticclockgenedisruptionandgutmicrobiotadysbiosisincircadianrhythmdisordermousemodel AT chitangho capsaicinalleviatesthehepaticclockgenedisruptionandgutmicrobiotadysbiosisincircadianrhythmdisordermousemodel AT yawenwang capsaicinalleviatesthehepaticclockgenedisruptionandgutmicrobiotadysbiosisincircadianrhythmdisordermousemodel AT jiexiao capsaicinalleviatesthehepaticclockgenedisruptionandgutmicrobiotadysbiosisincircadianrhythmdisordermousemodel AT muwenlu capsaicinalleviatesthehepaticclockgenedisruptionandgutmicrobiotadysbiosisincircadianrhythmdisordermousemodel |