Hirudo extract ameliorates proliferative vitreoretinopathy by promoting autophagy and attenuating the THBS2/PI3K/Akt pathway

Hirudo extract ameliorates proliferative vitreoretinopathy by promoting autophagy and attenuating the THBS2/PI3K/Akt pathway

Abstract Epithelial‒mesenchymal transition (EMT) in retinal pigment epithelial (RPE) cells is believed to play a key role in the pathogenesis of proliferative vitreoretinopathy (PVR). The ability of Hirudo to promote blood flow and dispel blood stasis may be related to its anti-EMT effects. Through...

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Bibliographic Details
Main Authors: Hui Huang, Qun Huang, Jing Wang, Wanjie Wang, Yanlin Zheng
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Proliferative vitreoretinopathy
Retinal pigment epithelial
Hirudo extract
Epithelial–mesenchymal transition
THBS2/PI3K/Akt abstract
Online Access:https://doi.org/10.1038/s41598-025-85882-7
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