Effects of sika deer antler protein on immune regulation and intestinal microbiota in mice
The medicinal use of pilose antler was first described in Shennong's Classic of Materia Medica for treating kidney yang deficiency. Therefore, in this study, sika deer antler protein (SDAP) was used as a component analysis and its impacts on the immunomodulatory effects of RAW264.7 cells and ki...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624006406 |
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| author | Kaiyue Liu Ke Zhang Yang Yang Ying Zong Zhongmei He Weijia Chen Jianming Li Rui Du |
| author_facet | Kaiyue Liu Ke Zhang Yang Yang Ying Zong Zhongmei He Weijia Chen Jianming Li Rui Du |
| author_sort | Kaiyue Liu |
| collection | DOAJ |
| description | The medicinal use of pilose antler was first described in Shennong's Classic of Materia Medica for treating kidney yang deficiency. Therefore, in this study, sika deer antler protein (SDAP) was used as a component analysis and its impacts on the immunomodulatory effects of RAW264.7 cells and kidney yang deficiency mice, as well as the intestinal flora of mice, were investigated. The results showed that SDAP could regulate the secretion of associated factors and the expression of genes and proteins of NF-κB-related signaling pathway in RAW264.7 cells induced by lipopolysaccharide and kidney yang deficiency mice. Additionally, SDAP could regulate intestinal homeostasis by increasing the abundance of beneficial bacteria Lactobacillus and Clostridium, reducing the abundance of pathogenic bacteria Proteobacteria, and maintaining some bacterial homeostasis in kidney-yang deficiency mice, so as to decrease intestinal edema, effectively improve intestinal microecology, and improve the immune function of the organism. |
| format | Article |
| id | doaj-art-4d5a9969deaf4e94af006cd7f03957a3 |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-4d5a9969deaf4e94af006cd7f03957a32025-01-12T05:24:44ZengElsevierJournal of Functional Foods1756-46462025-01-01124106637Effects of sika deer antler protein on immune regulation and intestinal microbiota in miceKaiyue Liu0Ke Zhang1Yang Yang2Ying Zong3Zhongmei He4Weijia Chen5Jianming Li6Rui Du7College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, ChinaCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, ChinaCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, ChinaCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China; Jilin Provincial Engineering Research Center for Efficient Breeding and Product Development of Sika Deer, Jilin Agricultural University, Changchun 130118, China; Corresponding authors at: College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China; Jilin Provincial Engineering Research Center for Efficient Breeding and Product Development of Sika Deer, Jilin Agricultural University, Changchun 130118, ChinaCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China; Jilin Provincial Engineering Research Center for Efficient Breeding and Product Development of Sika Deer, Jilin Agricultural University, Changchun 130118, ChinaCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China; Jilin Provincial Engineering Research Center for Efficient Breeding and Product Development of Sika Deer, Jilin Agricultural University, Changchun 130118, ChinaCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China; Jilin Provincial Engineering Research Center for Efficient Breeding and Product Development of Sika Deer, Jilin Agricultural University, Changchun 130118, China; Corresponding authors at: College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.The medicinal use of pilose antler was first described in Shennong's Classic of Materia Medica for treating kidney yang deficiency. Therefore, in this study, sika deer antler protein (SDAP) was used as a component analysis and its impacts on the immunomodulatory effects of RAW264.7 cells and kidney yang deficiency mice, as well as the intestinal flora of mice, were investigated. The results showed that SDAP could regulate the secretion of associated factors and the expression of genes and proteins of NF-κB-related signaling pathway in RAW264.7 cells induced by lipopolysaccharide and kidney yang deficiency mice. Additionally, SDAP could regulate intestinal homeostasis by increasing the abundance of beneficial bacteria Lactobacillus and Clostridium, reducing the abundance of pathogenic bacteria Proteobacteria, and maintaining some bacterial homeostasis in kidney-yang deficiency mice, so as to decrease intestinal edema, effectively improve intestinal microecology, and improve the immune function of the organism.http://www.sciencedirect.com/science/article/pii/S1756464624006406Sika deer antlerAntler proteinKidney yang deficiencyImmune regulationIntestinal flora |
| spellingShingle | Kaiyue Liu Ke Zhang Yang Yang Ying Zong Zhongmei He Weijia Chen Jianming Li Rui Du Effects of sika deer antler protein on immune regulation and intestinal microbiota in mice Journal of Functional Foods Sika deer antler Antler protein Kidney yang deficiency Immune regulation Intestinal flora |
| title | Effects of sika deer antler protein on immune regulation and intestinal microbiota in mice |
| title_full | Effects of sika deer antler protein on immune regulation and intestinal microbiota in mice |
| title_fullStr | Effects of sika deer antler protein on immune regulation and intestinal microbiota in mice |
| title_full_unstemmed | Effects of sika deer antler protein on immune regulation and intestinal microbiota in mice |
| title_short | Effects of sika deer antler protein on immune regulation and intestinal microbiota in mice |
| title_sort | effects of sika deer antler protein on immune regulation and intestinal microbiota in mice |
| topic | Sika deer antler Antler protein Kidney yang deficiency Immune regulation Intestinal flora |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624006406 |
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