DNA methylation, histone acetylation in the regulation of memory and its modulation during aging
Memory formation is associated with constant modifications of neuronal networks and synaptic plasticity gene expression in response to different environmental stimuli and experiences. Dysregulation of synaptic plasticity gene expression affects memory during aging and neurodegenerative diseases. Cov...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Aging |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fragi.2024.1480932/full |
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| author | Padmanabh Singh Vijay Paramanik |
| author_facet | Padmanabh Singh Vijay Paramanik |
| author_sort | Padmanabh Singh |
| collection | DOAJ |
| description | Memory formation is associated with constant modifications of neuronal networks and synaptic plasticity gene expression in response to different environmental stimuli and experiences. Dysregulation of synaptic plasticity gene expression affects memory during aging and neurodegenerative diseases. Covalent modifications such as methylation on DNA and acetylation on histones regulate the transcription of synaptic plasticity genes. Changes in these epigenetic marks correlated with alteration of synaptic plasticity gene expression and memory formation during aging. These epigenetic modifications, in turn, are regulated by physiology and metabolism. Steroid hormone estrogen and metabolites such as S-adenosyl methionine and acetyl CoA directly impact DNA and histones’ methylation and acetylation levels. Thus, the decline of estrogen levels or imbalance of these metabolites affects gene expression and underlying brain functions. In the present review, we discussed the importance of DNA methylation and histone acetylation on chromatin modifications, regulation of synaptic plasticity gene expression and memory consolidation, and modulation of these epigenetic marks by epigenetic modifiers such as phytochemicals and vitamins. Further, understanding the molecular mechanisms that modulate these epigenetic modifications will help develop recovery approaches. |
| format | Article |
| id | doaj-art-4d5a1de7e9fa4bafb5c7b0e2f8b08042 |
| institution | Kabale University |
| issn | 2673-6217 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging |
| spelling | doaj-art-4d5a1de7e9fa4bafb5c7b0e2f8b080422025-01-06T06:59:09ZengFrontiers Media S.A.Frontiers in Aging2673-62172025-01-01510.3389/fragi.2024.14809321480932DNA methylation, histone acetylation in the regulation of memory and its modulation during agingPadmanabh SinghVijay ParamanikMemory formation is associated with constant modifications of neuronal networks and synaptic plasticity gene expression in response to different environmental stimuli and experiences. Dysregulation of synaptic plasticity gene expression affects memory during aging and neurodegenerative diseases. Covalent modifications such as methylation on DNA and acetylation on histones regulate the transcription of synaptic plasticity genes. Changes in these epigenetic marks correlated with alteration of synaptic plasticity gene expression and memory formation during aging. These epigenetic modifications, in turn, are regulated by physiology and metabolism. Steroid hormone estrogen and metabolites such as S-adenosyl methionine and acetyl CoA directly impact DNA and histones’ methylation and acetylation levels. Thus, the decline of estrogen levels or imbalance of these metabolites affects gene expression and underlying brain functions. In the present review, we discussed the importance of DNA methylation and histone acetylation on chromatin modifications, regulation of synaptic plasticity gene expression and memory consolidation, and modulation of these epigenetic marks by epigenetic modifiers such as phytochemicals and vitamins. Further, understanding the molecular mechanisms that modulate these epigenetic modifications will help develop recovery approaches.https://www.frontiersin.org/articles/10.3389/fragi.2024.1480932/fullDNA methylationhistone acetylationlearning and memoryagingphytochemials |
| spellingShingle | Padmanabh Singh Vijay Paramanik DNA methylation, histone acetylation in the regulation of memory and its modulation during aging Frontiers in Aging DNA methylation histone acetylation learning and memory aging phytochemials |
| title | DNA methylation, histone acetylation in the regulation of memory and its modulation during aging |
| title_full | DNA methylation, histone acetylation in the regulation of memory and its modulation during aging |
| title_fullStr | DNA methylation, histone acetylation in the regulation of memory and its modulation during aging |
| title_full_unstemmed | DNA methylation, histone acetylation in the regulation of memory and its modulation during aging |
| title_short | DNA methylation, histone acetylation in the regulation of memory and its modulation during aging |
| title_sort | dna methylation histone acetylation in the regulation of memory and its modulation during aging |
| topic | DNA methylation histone acetylation learning and memory aging phytochemials |
| url | https://www.frontiersin.org/articles/10.3389/fragi.2024.1480932/full |
| work_keys_str_mv | AT padmanabhsingh dnamethylationhistoneacetylationintheregulationofmemoryanditsmodulationduringaging AT vijayparamanik dnamethylationhistoneacetylationintheregulationofmemoryanditsmodulationduringaging |